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Weight loss induced by gastric implant in rats

Effects of capsaicin sensory denervation

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Abstract

To study the efficacy and mechanism of action of the intragastric bubble, 1- to 5-ml silicone bubbles were surgically implanted into the stomachs of 10- to 12-week-old female rats. To test the hypothesis that the satiety effects of the implant are mediated by visceral sensory nerves, a subgroup was treated as neonates with the sensory neurotoxin capsaicin, 50 mg/kg subcutaneously. In control animals, the implants caused a transient decrease in body weight, compared to sham-implanted animals, most evident at three days and abolished by 18 days after operation. In contrast, capsaicin-treated animals did not lose weight in response to gastric implantation. Substance P was decreased in the vagus nerves of capsaicin-treated animals, confirming sensory denervation. At autopsy, all gastric implanted rats had enlarged stomachs. We conclude that intact sensory innervation is essential for weight loss in response to the gastric bubble.

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Author notes

  1. David B. MacLean MD

    Present address: Division of Endocrinology, Rhode Island Hospital, 593 Eddy Street, Providence, Rhode Island

Authors and Affiliations

  1. Departments of Medicine and Pathology, The Bowman Gray School of Medicine of Wake Forest University, 27103, Winston-Salem, North Carolina

    Margaret G. Northway PhD, FCP, Kim R. Geisinger MD, John H. Gilliam MD & David B. MacLean MD

Authors
  1. Margaret G. Northway PhD, FCP
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  2. Kim R. Geisinger MD
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  3. John H. Gilliam MD
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  4. David B. MacLean MD
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Northway, M.G., Geisinger, K.R., Gilliam, J.H. et al. Weight loss induced by gastric implant in rats. Digest Dis Sci 37, 1051–1056 (1992). https://doi.org/10.1007/BF01300286

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  • DOI: https://doi.org/10.1007/BF01300286

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