Summary
Three types of cytopathogenicity produced by herpes simplex virus in HeLa cell cultures have been described. The predominant lesions produced are proliferative (P), rounding without proliferation (NP), and giant-cells with lysis (GC). The response of HeLa cells to infection with herpes virus strains producing each of these 3 types of cytopathogenicity has been studied quantitatively.
The proliferative virus strain was characterized by a rapid increase in the number of cells while the strains producing the other two were characterized by a slight or profound decrease in cell numbers. The rate of virus release in each of these types is also reported.
Some of the factors associated with the development of the three types of cytopathogenicity in HeLa as well as several other cell strains are recorded.
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This work was supported by a grant-in-aid from the United States Public Health Service, National Institutes of Health.
Post-doctorate Fellow, United States Public Health Service.
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Gray, A., Tokumaru, T. & Scott, T.F.M. Different cytopathogenic effects observed in HeLa cells infected with herpes simplex virus. Archiv f Virusforschung 8, 59–76 (1958). https://doi.org/10.1007/BF01242313
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DOI: https://doi.org/10.1007/BF01242313