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Metabolic studies on toxic compounds

5. Identification of new methylhippuric acids

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Summary

Two new aromatic acids, 3,4- and 3,5-dimethylhippuric acids, have been prepared by reacting acid chlorides of corresponding benzoic acids with sodium glycinate. Their physico-chemical properties and spectroscopic patterns (ultraviolet and infrared) have been described in this report as well as a method of identification by thin-layer chromatography.

Zusammenfassung

3,4- und 3,5-Dimethylhippursäure, zwei neue aromatische Säuren, wurden durch Einwirkung der entsprechenden Benzoesäurechloride auf Natriumglycinat hergestellt. Ihre physikalisch-chemischen Eigenschaften, ihre UV- und IR-Spektren angegeben und ihr Nachweis durch Dünnschichtchromatographie beschrieben.

Résumé

Deux nouveaux acides aromatiques, les acides diméthyl-3, 4- et diméthyl-3, 5-hippuriques ont été synthétisés en faisant réagir les chlorides des acides benzoïques correspondants sur le glycinate de sodium. Leurs propriétés physico-chimiques et leurs caractéristiques spectroscopiques (dans l'ultraviolet et l'infrarouge) ont été décrites dans ce rapport ainsi qu'une méthode d'identification par Chromatographie sur couche mince.

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References

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Authors and Affiliations

  1. Biomedical Unit of Occupational Health Division, Department of National Health and Welfare, Environmental Toxicology Programme, Ottawa, Canada

    Souheil Laham, Marc Potvin & Elmera O. Matutina

Authors
  1. Souheil Laham
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  2. Marc Potvin
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  3. Elmera O. Matutina
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Laham, S., Potvin, M. & Matutina, E.O. Metabolic studies on toxic compounds. Mikrochim Acta 57, 654–659 (1969). https://doi.org/10.1007/BF01216470

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  • DOI: https://doi.org/10.1007/BF01216470

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