Summary
The influence of lactic acid on rat adipose tissue lipolysis was studiedin vitro. Good correlation was found between lactic acid concentration in the medium and inhibition of lipolysis. The correlation was equally good between pyruvate production into the medium and/or lactate to pyruvate ratios and inhibition of lipolysis. So far no answer can be given whether the observed inhibition of lipolysis is a direct or indirect (pyruvate) metabolic effect of lactic acid. The possibility of an inhibition of lipolysis mediated by lactic acid during muscular exercise is discussed.
Résumé
L'influence de l'acide lactique sur la lipolyse a été étudiéein vitro sur le tissu adipeux du rat. L'acide lactique inhibe la lipolyse en proportion de la dose appliquée. Il y avait également une bonne corrélation entre l'inhibition de la lipolyse et la production de pyruvate dans le milieu et/ou les rapports lactate sur pyruvate. On ne peut distinguer, si l'inhibition de la lipolyse est un effet métabolique direct de l'acide lactique ou dépend de la production de pyruvate. L'inhibition de la lipolyse par l'acide lactique pendant le travail musculairein vivo est discutée.
Zusammenfassung
Der Einfluß von Milchsäure auf die Lipolyse wirdin vitro am isolierten Fettgewebe untersucht. Milchsäure bewirkt eine dosisabhängige Hemmung der Lipolyse. Es kann nicht entschieden werden, ob die Antilipolyse ein direkter Stoffwechseleffekt der Milchsäure ist oder nur durch diese vermittelt wird. Auffällig ist die zunehmende Hemmung der Lipolyse mit Anstieg des Redox-Potentials. Die Möglichkeit einer lactatbedingten Lipolysehemmungin vivo während muskulärer Arbeit wird diskutiert.
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Herrn Prof. Dr. Dr. Gustav Bodechtel zum 70. Geburtstag in Verehrung gewidmet.
Mit Unterstützung der Deutschen Forschungsgemeinschaft.
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Dieterle, P., Dieterle, C., Bottermann, P. et al. In vitro versuche zur antilipolytischen Wirkung von Milchsäure. Diabetologia 5, 238–242 (1969). https://doi.org/10.1007/BF01212091
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DOI: https://doi.org/10.1007/BF01212091