Summary
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1.
A general method was developed for the synthesis of cyclic acetals of β -keto aldehydes by reaction of β -chlorovinyl ketones with ethylene glycol in presence of alkaline agents. Yields of 50–85% were obtained.
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2.
It was shown that heating of open-chain β -keto acetals with ethylene glycol in presence of alkali results in transacetalization with formation of the corresponding cyclic acetals.
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3.
It was shown that the use of cyclic acetals for the synthesis of alkylnaphthalenes by the method that we developed previously [8] makes it possible to obtain these naphthalenes in higher yield.
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Kochetkov, N.K., Nifantyev, E.E. & Nesmeyanov, A.N. Cyclic acetals of β-keto aldehydes and their use in synthesis of alkylnaphthalenes. Russ Chem Bull 6, 977–982 (1957). https://doi.org/10.1007/BF01173593
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DOI: https://doi.org/10.1007/BF01173593