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Preferential uptake of intravenously administered hyaluronidase (Hyalosidase) by damaged rat myocardium

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Bioscience Reports

Abstract

The induction of myocardial infarction in rats by ligation of the left - anterior coronary artery was confirmed by measurement of increased plasma levels of creatine kinase, aspartate aminotransferase and lactate dehydrogenase. Using this model system it has been established t h a t intravenous administration of 12SI-labelled hyaluronidase to rats resulted in a preferential uptake of the enzyme by damaged myocardium as compared to normal heart tissue.

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Authors and Affiliations

  1. Department of Biochemistry, University College, P. O. Box 78, CF1 1XL, Cardiff, Wales, UK

    Kenneth S. Dodgson

  2. Biorex Laboratories Ltd., Biorex House, Canonbury Villas, N1 2HB, London, UK

    Julia S. Earnshaw, Kheng H. Peh, Anthony H. Olavesen & Peter Gacesa

Authors
  1. Julia S. Earnshaw
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  2. Kheng H. Peh
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  3. Kenneth S. Dodgson
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  4. Anthony H. Olavesen
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  5. Peter Gacesa
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Earnshaw, J.S., Peh, K.H., Dodgson, K.S. et al. Preferential uptake of intravenously administered hyaluronidase (Hyalosidase) by damaged rat myocardium. Biosci Rep 5, 329–334 (1985). https://doi.org/10.1007/BF01116905

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  • DOI: https://doi.org/10.1007/BF01116905

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