Experiments on rats with acute myocardial ischemia accompanied by early postocclusive arrhythmias have shown normalizing, energy-stabilizing, and antiarrhythmic effects of uridine and uridine-5’-monophosphate. The drugs decreased lactate and restored reserves of glycogen and creatine phosphate depleted by ischemia. Uridine and uridine-5’-monophosphate significantly decreased the severity of ventricular arrhythmias. Both drugs reduced the incidence and duration of fibrillation. Uridine -5’-monophosphate demonstrated most pronounced antifibrillatory effectiveness. We hypothesize that the antiarrhythmic effect of the drugs is determined by their capacity to activate energy metabolism.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 157, No. 6, pp. 696-699, June, 2014
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Bul’on, V.V., Krylova, I.B., Selina, E.N. et al. Antiarrhythmic Effect of Uridine and Uridine-5’-Monophosphate in Acute Myocardial Ischemia. Bull Exp Biol Med 157, 728–731 (2014). https://doi.org/10.1007/s10517-014-2653-3
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DOI: https://doi.org/10.1007/s10517-014-2653-3