Abstract
This lecture outlines the early stages in the discovery of adrenaline β-receptor antagonists and of the histamine H2-receptor antagonists. It ends with a brief personal view about future research.
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References
Ahlquist, R. P. (1948).Am. J. Physiol. 153:586.
Ariens, E. J. (1954)Archs. Int. Pharmacodyn. Ther. 99:32.
Ash, A. S. F. and Schild, H. O. (1966)Br. J. Pharmacol. 27:427.
Black, J. W. (1973) In:Int. Symp. on Histamine H 2-Receptor Antagonists, (ed. Wood, C. J. and Simkins, M. A.), Smith Kline and French, Welwyn Garden City, UK, pp. 219.
Black, J. W., Crowther, A. F., Shanks, R. G., Smith, L. H. and Dornhorst, A. C. (1964)Lancet i: 1080.
Black, J. W., Duncan, W. A. M., Durant, G. J., Ganellin, C. R. and Parsons, M. E. (1972)Nature (London) 236:385.
Black, J. W., Duncan, W. A. M. and Shanks, R. G. (1965)Br. J. Pharmacol. 25:577.
Black, J. W., Fisher, E. W. and Smith, A. N. (1958).J. Physiol. 141:27.
Black, J. W., Jenkinson D. H. and Kenakin, T. P. (1980)Eur. J. Pharmacol. 65: 1.
Black, J. W. and Leff, P. (1983)Proc. Roy. Soc. B. 220:141.
Black, J. W., Leff, P., Shankley, N. P. and Wood J. (1985a)Br. J. Pharmacol. 84: 561.
Black, J. W., Leff, P. and Shankley, N.P. (1985b)Br. J. Pharmacol. 86:589.
Black, J. W. and Stephenson, J. S. (1962)Lancet ii:311.
Cannon, W. B. and Rosenbleuth, A., (1939) In:Autonomic Neuroeffector Mechanisms The Macmillan Co., New York.
Clark, A. J. (1933). In:The Mode of Action of Drugs in Cells, Edward Arnold Co., London.
Code, C. F. (1965)Fed. Proc. 24:1311.
Dale, H. H. (1906)J Physiol. London 34:163.
Dornhorst, A. C. and Robinson, B. F. (1962)Lancet ii:314.
Edelman, G. M. (1984)Ann. Rev. Neurosci. 7:339.
Folkow, B., Maeger, K. and Kahlson, G. (1948)Acta Physiol. Scand. 15:264.
Ghosh, M. N. and Schild, H. O. (1958)Br. J. Pharmacol. Chemother. 13:54.
Grossman, S. P. (1967) In:Handbook of Physiology,1 Washington, USA, Sect. 6, pp. 287.
Hokfelt, T., Millhorn, D., Seroogy, K., Tsuruo, Y., Ceccatelli, S., Lindh, B., Meister, D., Melander, T., Schalling, M., Bartfai, T. and Terenius, L. (1987) Experientia43:768.
Kahlson, G. and Rosengren, E. (1972)Experientia 28:993.
Kenakin, T. P. and Beek, D. (1980)J. Pharmacol. Exp. Ther. 213:406.
Konzett, H. (1940)N. Arch. Exp. Path. Pharmak. 197:27.
Leff, P., Martin, G. R. and Morse, J. M. (1985)Br. J. Pharmacol. 85:655.
Loew, E. R. (1947)Physiol. Rev. 27:542.
MacIntosh, F. C. (1938)Quart. J. Exp. Physiol. 28:87.
Moran, N. C. and Perkins, M. E. (1958)J. Pharmacol. Exp. Ther. 124:223.
Parsons, M. E. (1969)Quantitative studies of drug-induced acid gastric secretion. PhD Thesis, University of London.
Powell, C. E. and Slater, I. H. (1958)J. Pharmac. Exp. Ther. 122:480.
Smith, G. and Lawson, D. D. (1958)Scot. Med. J. 3:346.
Sperry, R. W. (1963)Proc. Natl. Acad. Sci. USA 50:703.
Stephenson, R. P. (1956)Br. J. Pharmacol. 11:379.
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Published inLes Prix Nobel 1988, printed in Sweden by Norstedts Tryckeri, Stockholm, Sweden, 1989, republished here with the permission of the Nobel Foundation, the Copyright holder.
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Black, J. Drugs from emasculated hormones: The principle of syntopic antagonism. Biosci Rep 9, 253–272 (1989). https://doi.org/10.1007/BF01114681
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DOI: https://doi.org/10.1007/BF01114681