Abstract
In conscious cats with gastric fistulae and the diversion of bile and pancreatic juice to jejunum, secretin (1 unit/kg-hr), cholecystokinin (CCK) (4 units/kg-hr), and duodenal acidification (1 mEq HCl/hr) caused a marked inhibition of half maximal gastric acid response to pentagastrin (8 μg/kg-hr) but did not alter the response to histamine (160 μg/kg-hr). Secretin, CCK, and jejunal acidification prevented the formation of duodenal ulcerations in conscious cats infused with pentagastrin or histamine for 36 hours. The antiulcer action of the intestinal hormones can be attributed to their inhibitory effect on gastric acid secretion and to the stimulation of pancreatic juice and bile secretion resulting in the increased neutralization of gastric acid in the duodenum.
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Konturek, S.J., Radecki, T., Thor, P. et al. Effect of intestinal hormones on pentagastrin- and histamine-evoked gastric acid secretion and duodenal ulcerations in cats. Digest Dis Sci 18, 135–141 (1973). https://doi.org/10.1007/BF01073157
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DOI: https://doi.org/10.1007/BF01073157