Abstract
Preoperative and postoperative anterior chamber fluorophotometry were performed after intravenous administration of fluorescein sodium in patients undergoing extracapsular extraction and posterior chamber lens implantation. The topical application of aqueous flurbiprofen sodium 0.03% solution before and after surgery significantly decreased the surgery mediated disturbance of the blood aqueous barrier as compared to vehicle application (placebo controlled). In contrast to similar studies, cortical steroids were not given topically or systemically to either group of patients during the study. The present fluorophotometric results correlate well with slitlamp biomicroscopy of postoperative inflammation. The data of this study indicate that flurbiprofen ophthalmic solution is effective in protecting the blood aqueous barrier (BAB) in human eyes during cataract surgery and IOL implantation.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Adams SS, Buckler JW. Ibuprofen and Flurbiprofen. Clinics in Rheumatic Diseases 1979; 5 No 2.
Araie M, Sawa M, Takase M. Effect of Topical Indometacin on the Blood-Aqueous Barrier After Intracapsular Extraction of Senile Cataract — A Fluorophotometric Study. Am J Ophthalmol 1981; 25: 237–247.
Araie M, Sawa M, Takase M. Topical Flurbiprofen and Diclofenac Suppress Blood-Aqueous Barrier Breakdown in Cataract Surgery: A Fluorophotometric Study. Jpn J Ophthalmol 1983; 27: 535–542.
Araie M, Takase M. Effects of S-596 and carteolol, new beta-adrenergic blockers, and flurbiprofen on the human eye: a fluorophotometric study. Graefe's Arch Clin Exp Ophthalmol 1985; 222: 259–262.
Bizzotto MF, De Franco I, Carillio F. Efficacy of Flurbiprofen versus Placebo on postoperative course following cataract extraction. Drugs Exptl Clin Res 1984; X(6): 421–425.
Crook D, Collins AJ, Rose AJ. A comparison of the effect of flurbiprofen on prostaglandin synthetase from human rheumatoid synovium and enzymatically active animal tissues. Communications, J Pharm Pharmac 1976; 28: 535.
Eakins KE. Prostaglandin and Non-Prostaglandin Mediated Breakdown of the Blood-Aqueous Barrier. Exp Eye Res 1977; Suppl: 483–498.
Ehrlich P. Ueber provocirte Fluorescenzerscheinungen am Auge. Versammlung der Charité-Aerzte 10.3.19881.
Ferreira SH, Vane JR. Prostaglandins: Their Disappearance from and Release into the Circulation. Nature 1967; 216.
Flach AJ. Nonsteroidal Anti-inflammatory Drugs. Ophthalmol Clinics of North America 1989; 2: 1.
Van Haeringen NJ, Glasius E, Oosterhuis JA, van Delft JL. Drug Prevention of Blood-Aqueous Barrier Disruption. Ophthalmic Res 1983; 15: 180–184.
Hillman JS, Frank GJ, Kheskani MB. Flurbiprofen and Human Intraocular Inflammation. Advances in Prostaglandins and Thromboxane Res 1980; 8, Raven Press, New York.
Kraff MC, Sanders DR, Jampol LM, Peyman GA, Lieberman HL. Prophylaxis of Pseudophakic Cystoid Macular Edema with Topical Indomethacin. Ophthalmology 1982; 89: 8.
Lepper RD, Trier HG. A New Device for Ocular Biometry. Docum Ophthal Proc Series 1981; 29.
Maloney WF, Grindle L. Textbook of Phacoemulsification. Lasenda Publ., 1590 Via Chaparral, Fallbrook, CA, 1988.
Miyake K, Sugiyama S, Norimatsu I, Ozawa T. Prevention of Cystoid Macula Edema after Lens Extraction by Topical Indomethacin (III) Radio-immunoassey Measurement of Prostaglandins in the Aqueous during and after Lens Extraction Procedures. Graefe's Arch klin exp Ophthalmol 1978; 209: 83–88.
Miyake K, Asakura M, Maekubo K. Consensual Reactions of Human Blood-Aqueous Barrier to Implant Operations. Arch Ophthalmol 1984; 102: 558–561.
Miyake K. Fluorophotometric evaluation of the blood-ocular barrier function following cataract surgery and intraocular lens implantation. J Cat Refract Surg 1988; 14: 560–568.
Pham Duy T, Becker HU, Wollensak J, Tievenow N. Einfluβ der E.C. Kataraktoperation und Hinterkammerlinse-nimplantation auf die Blut-Kammerwasserschranke.
Polansky JR, Weinreb RN. Anti-Inflammatory Agents, Steroids as Anti-Inflammatory Agents. In: Handbook of Experimental Pharmacology, Pharmacology of the Eye, Sears ML (Ed) 1984; 69: 459–538, Springer, Berlin.
Sanders DR, Kraff MC, Lieberman HL, Peyman GA, Tarabishy S. Breakdown and Reestablishment of Blood-Aqueous Barrier With Implant Surgery. Arch Ophthalmol 1982; 100: 588–590.
Sanders DR, Kraff M. Steroidal and Nonsteroidal Anti-inflammatory Agents. Arch Ophthalmol 1984; 102: 1453–1456.
Sawa M, Araie M, Tanishima T. A Fluorophotometric Study of the Barrier Functions in the Anterior Segment of the Eye after Intracapsular Cataract Extraction. Jpn J Ophthalmol 1983; 27: 404–415.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Diestelhorst, M., Aspacher, F., Konen, W. et al. The effect of flurbiprofen 0.03% eye drops on the blood aqueous barrier in extracapsular cataract extraction with IOL implantation. Int Ophthalmol 15, 69–73 (1991). https://doi.org/10.1007/BF01046423
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01046423