Abstract
The effects of S-596 and coarteolol, new beta-adrenergic blockers, were studied by means of the oral fluorescein method. Transfer coefficients by diffusion,k d ⋅ pa, and by flow,k fa, were estimated in a total of 11 normal young volunteers, in whom the drug was instilled in one eye and the placebo in the fellow eye. With 0.5% dl-S-596,k d ⋅ pa increased to 124 ± 9% (mean ± SD) andk fa decreased to 67 ± 10% of the control eye. With 1% dl-carteolol,k d ⋅ pa increased to 121 ± 4%, andk fa decreased to 84 ± 11% of the control eye. Both S-596 and carteolol increased iris permeability and decreased the aqueous flow rate significantly.
In a group of 13 cases, intracapsular extraction of senile cataract was carried out with postoperative routine instillations, and in another group of 7 cases, it was carried out with additional topical flurbiprofen, a new nonsteroidal anti-inflammatory drug. Flurbiprofen ophthalmic solution (0.1%) was instilled 3, 2, 1, and 0.5 h before the surgery and 4 times a day postoperatively. On the 6th postoperative day, a fluorophotometric study was carried out using oral fluorescein, and a coefficient that reflects the permeability of the blood-aqueous barrier after the cataract surgery was calculated. It was found that additional topical flurbiprofen considerably suppresses the disruption of the blood-aqueous barrier.
Similar content being viewed by others
References
Araie M, Takase M (1981) Effects of various drugs on aqueous humor dynamics in man. Jpn J Ophthalmol 25:91–111
Araie M, Sawa M, Nagataki S, Mishima S (1980) Aqueous humor dynamics in man as studied by oral fluorescein. Jpn J Ophthalmol 24:346–362
Araie M, Sawa M, Takase M (1981) Effect of topical indomethacin on the blood-aqueous barrier after intracapsular extraction of senile cataract. A fluorophotometric study. Jpn J Ophthalmol 25:237–247
Azuma I, Nakajima M, Shibahara S, Hirano T (1982) S-596, a beta-adrenergic blocking agent for the treatment of glaucoma. Presented at the Second Annual Meeting of the Association for Ophthalmic Pharmacology, Kyoto, Japan
Beardsley TL, Shields MB (1982) An effect of timolol on aqueous humor protein concentration. ARVO Abstract 39
Eguchi K, Ohara K, Tobari I, Fukado Y, Uchida Y, Majima Y, Miyake K, Mishima S, Masuda K (1984) Effects of topical indomethacin on suppression of inflammation after ocular surgery 1. Double masked study of anti-inflammatory effects on the intracapsular lens extraction. Acta Soc Ophthalmol Jpn (in press)
Hara Y, Sato E, Miyagishi A, Aisaka A, Hibino T (1978) Synthesis and beta-adrenergic blocking action of a new thiazolylthiopropanolamine derivative. J Pharm Sci 67:1334–1335
Hara Y, Sata E, Miyagishi A, Aono S, Nakatani H (1979) Pharmacological properties of dl-2-(3′-t-butylamino-2′-hydroxypropylthio)-4-(5′-carbamoyl-2′-thienyl)-thiazole hydrochrolide (S-596), a new beta-adrenergic blocking agent. Folia Pharmacol Jpn 75:707–720
Horie T, Takahashi O, Shirato S, Kitazawa Y (1984) A comparative study of the ocular hypotensive effect of timolol and carteolol. Jpn J Clin Ophthalmol (in press)
Kinsey VE, Palm E (1955) Posterior and anterior chamber aqueous formation. Arch Ophthalmol 53:330–344
Masumoto S, Masuda C (1976) The mechanism of anti-inflammatory action of 2-(2-fluoro-4-biphenylyl) propionic acid (flurbiprofen). Folia Pharmacol Jpn. 72:753–762
Miyake K, Sugiyama S, Norimatsu I, Ozawa T (1978) Prevention of cystoid macular edema after lens extraction by topical indomethacin. (III) Radioimmunoassay measurement of prostaglandins in the aqueous during and after lens extraction procedure. Graefe's Arch Clin Exp Ophthalmol 209:83–88
Miyake K, Sakamura S, Miura H (1980) Long-term follow-up study on prevention of aphakic cystoid macular oedema by topical indomethacin. Br J Ophthalmol 64:324–328
Mochizuki M, Sawa M, Masuda K (1977) Topical indomethacin in intracapsular extraction of senile cataract. Jpn J Ophthalmol 21:215–226
Perkins ES (1975) Prostaglandins and the eye. Adv Ophthalmol 29:2–21
Podos SM, Becker B (1976) Comparison of ocular prostglandin synthesis inhibitors. Invest Ophthalmol 15:841–844
Szaley J (1980) Effect of beta adrenergic agents on blood vessels of the rat iris. II. Morphological modifications of the vessel wall. Exp Eye Res 31:299–311
Szalay J, Fliegenspan J, Zaager A, Tobin G, Cross S (1980) Effect of beta adrenergic agents on blood vessels of the rat iris. I. Permeability to carbon particles. Exp Eye Res 31:289–297
Virdi PS, Hayreh SS (1980) Effect of pilocarpine, timolol and epifrin in iris vessel in rhesus monkeys. ARVO Abstract 82–83
Yabuuchi Y, Kinoshita D (1974) Cardiovascular studies of 5-(3-tert-butylamino-2-hydroxy) propoxy-3,4-dihydrocarbostyril hydrochloride (OPC-1085), a new potent beta-adrenergic blocking agent. Jpn J Pharmacol 24:853–861
Zimmerman TJ, Boger WP III (1979) The beta-adrenergic blocking agents and the treatment of glaucoma. Surv Ophthalmol 23:347–362
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Araie, M., Takase, M. Effects of S-596 and carteolol, new beta-adrenergic blockers, and flurbiprofen on the human eye: A fluorophotometric study. Graefe's Arch Clin Exp Ophthalmol 222, 259–262 (1985). https://doi.org/10.1007/BF02133693
Issue Date:
DOI: https://doi.org/10.1007/BF02133693