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Prevention of cystoid macular edema after lens extraction by topical indomethacin (III) radioimmunoassay measurement of prostaglandins in the aqueous during and after lens extraction procedures

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Summary

The amounts of Prostaglandin (PG) E and F2α in the aqueous humor were measured by radioimmunoassay techniques before and immediately after intracapsular and extracapsular cataract extractions. We found that:

  1. 1.

    The levels of PG E and PG F2α are elevated by cataract extraction.

  2. 2.

    The elevated levels of PGs can all be prevented by preoperative applications of topical indomethacin.

  3. 3.

    No differences in the amounts of PGs biosynthesized during intracapsular and extracapsular lens extraction were found.

  4. 4.

    In some cases, the levels of PG E were still elevated one week after surgery.

These findings were used as the basis for our attempts to define the causes of cystoid macular edema (CME) following lens extractions.

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Authors and Affiliations

  1. Shozankai Medical Foundation, Miyake Eye Clinic Hospital, 1070-Kami 5, Higashiozone-cho, Kita-ku, 462, Nagoya, Japan

    Kensaku Miyake

  2. Department of Biomedical Chemistry, Faculty of Medicine, University of Nagoya, 65, Tsuruma-cho, Showa-ku, 466, Nagoya, Japan

    Satoru Sugiyama, Izumi Norimatsu & Takayuki Ozawa

Authors
  1. Kensaku Miyake
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  2. Satoru Sugiyama
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  3. Izumi Norimatsu
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  4. Takayuki Ozawa
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Miyake, K., Sugiyama, S., Norimatsu, I. et al. Prevention of cystoid macular edema after lens extraction by topical indomethacin (III) radioimmunoassay measurement of prostaglandins in the aqueous during and after lens extraction procedures. Albrecht von Graefes Arch. Klin. Ophthalmol. 209, 83–88 (1978). https://doi.org/10.1007/BF00407841

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  • DOI: https://doi.org/10.1007/BF00407841

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