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Modeling the effect of oxygen mass transfer on β-lactam antibiotic production by immobilizedCephalosporium acremonium

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Summary

The oxygen effect on the production of β-lactam antibiotics was investigated whenCephalosporium acremonium was immobilized in calcium alginate. Theoretical effectiveness factors were calculated and compared with experimental ones. The approximate expressions of effectiveness factors reported in the literature were compared with the numerically obtained solutions to provide the best approximated expression for immobilizedC. acremonium cells. Yamane's approximate expression of effectiveness factor was best fit with the solutions numerically obtained in this investigation.

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Authors and Affiliations

  1. Department of Chemical Engineering, Texas Tech University, 79409, Lubbock, Texas, USA

    Yong Ho Khang, Hariharan Shankar & Fred Senatore

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  1. Yong Ho Khang
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  2. Hariharan Shankar
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  3. Fred Senatore
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Khang, Y.H., Shankar, H. & Senatore, F. Modeling the effect of oxygen mass transfer on β-lactam antibiotic production by immobilizedCephalosporium acremonium . Biotechnol Lett 10, 861–866 (1988). https://doi.org/10.1007/BF01026996

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