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The relation between baseline and 150 min platelet counts in response to selective beta-1-receptor blockade an experimental study on healthy subjects

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Summary

In 30 healthy volunteers after an oral administration of 50 mg metoprolol basal and 150 min platelet counts were determined. A significant negative correlation (p < 0.01) between the baseline platelet count and the percentage increase at 150 min was shown to be present. It is postulated that this observation reflects interindividual differences between the magnitude of the exchangeable splenic platelet pool.

Zusammenfassung

Bei 30 gesunden Versuchspersonen wurde die periphere Thrombozytenzahl vor und 150 Minuten nach einer oralen Dosis von 50 mg Metoprolol bestimmt. Dabei fand sich eine signifikante (p < 0,01) negative Korrelation zwischen dem Ausgangswert und der prozentualen Zunahme nach 150 Minuten. Es wird angenommen, daß diese Beobachtung interindividuelle Unterschiede der austauschbaren Größe des Milzpools widerspiegelt.

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Authors and Affiliations

  1. Department of Medicine III, Sahlgren's Hospital, University of Göteborg, Göteborg

    K. Fredén,  J. Kutti, P. Lundborg & L. Vilén

  2. Medical Department, Hässle Research Laboratories, Mölndal, Sweden

    K. Fredén,  J. Kutti, P. Lundborg & L. Vilén

Authors
  1. K. Fredén
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  2. J. Kutti
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  3. P. Lundborg
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  4. L. Vilén
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Fredén, K., Kutti, J., Lundborg, P. et al. The relation between baseline and 150 min platelet counts in response to selective beta-1-receptor blockade an experimental study on healthy subjects. Blut 35, 373–375 (1977). https://doi.org/10.1007/BF00996623

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  • DOI: https://doi.org/10.1007/BF00996623

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