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The effects of monoamine oxidase B inhibition on dopamine metabolism in rats with nigro-striatal lesions

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Abstract

The purpose of this study was to examine whether monoamine oxidase type B (MAO-B) has a role in striatal dopamine metabolism in animals with a unilateral lesion of the medial forebrain bundle, and whether 2-phenylethylamine (PE) could have a role in amplification of dopamine (DA) responses in DA depleted striatum. Inhibition of MAO-B did not alter DA metabolism in lesioned striata. PE accumulation decreased with loss of DA as long as there was no DA dysfunction. In lesioned striata with dysfunction of DA transmission at the synaptic level, PE accumulation increased,suggesting a compensatory increase in PE synthesis. This increase in PE levels does not appear to be mediated by an increase in the total striatal aromaticl-amino acid decarboxylase (AADC) activity. We conclude that inhibition of MAO-B has no effect on DA metabolism in the hemi-parkinsonian rat striatum and that PE could be involved in the antiparkinsonian action of MAO-B inhibitors.

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Authors and Affiliations

  1. Neuropsychiatric Research Unit, University of Saskatchewan, A114 Medical Research Building, S7N 0W0, Saskatoon, Saskatchewan, Canada

    E. Scarr, D. M. Wingerchuk, A. V. Juorio & I. A. Paterson

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  1. E. Scarr
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  2. D. M. Wingerchuk
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  3. A. V. Juorio
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  4. I. A. Paterson
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Scarr, E., Wingerchuk, D.M., Juorio, A.V. et al. The effects of monoamine oxidase B inhibition on dopamine metabolism in rats with nigro-striatal lesions. Neurochem Res 19, 153–159 (1994). https://doi.org/10.1007/BF00966810

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