Conclusions
The optical antipodes of N-p-[di-(2-chloroethyl)amino]phenacetylvaline, methionine, and alanine were obtained by the acid chloride and N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline methods; the carbodiimide method and the activated cyanomethyl ester method give significant or complete racemization.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature cited
A. Elson, A. Haddow, F. Bergell, and J. Stock, Biochem. Pharmacol.,11, 1079 (1962).
N. E. Golubeva, O. V. Kil'disheva, and I. L. Knunyants, DokL Akad. Nauk SSSR,119, 83 (1958).
A. A. Aboderin, G. R. Delpierre, and J. S. Fruton, J. Amer. Chem. Soc.,87, 5469 (1965).
K. I. Karpavichyus, N. E. Golubeva, O. V. Kil'disheva, and I. L. Knunyants, Izv. Akad. Nauk SSSR, Otd. Khim. Nauk, 1299 (1961).
J. Muren and A. Weissman, J. Med. Chem.,14, 49 (1971).
Yu. Degutis and D. Dzhyuvene, Zh. Obshch. Khim.,33, 3746 (1963).
Author information
Authors and Affiliations
Additional information
Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 4, pp. 891–894, April, 1976.
Rights and permissions
About this article
Cite this article
Klyukene, R.B., Karpavichyus, K.I. & Kil'disheva, O.V. Synthesis of optical antipodes of N-p-[di-(2-chloroethyl)amino]phenacetylamino acids. Russ Chem Bull 25, 870–872 (1976). https://doi.org/10.1007/BF00922399
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00922399