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Changes in T-lymphocyte subsets during acute rheumatic fever

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Abstract

Relative proportions and numbers of helper [OKT4(+)] and suppressor [OKT8(+)] peripheral blood lymphocytes were examined in 32 young patients during the acute phase of rheumatic fever. No significant decrease in percentage T cells during acute rheumatic fever was noted in comparison to normal children controls from the same population. A decrease in absolute numbers of OKT4(+) T cells was also noted in acute rheumatic subjects not receiving corticosteroids (P<0.05). In addition, a significant decrease was documented in both proportions and total numbers of OKT8(+) putative suppressor cells during acute rheumatic attacks. C-reactive protein binding to T-lymphocyte subsets showed no preferential reactivityin vivo for suppressor or helper T cells. Antigen-reactive T lymphocytes identified with the T29 mouse hybridoma reagent showed similar proportions and numbers in rheumatic children as were noted in controls. The present data indicate profound alterations in both helper- and suppressor-cell types in the peripheral blood profile of children with acute rheumatic fever.

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Authors and Affiliations

  1. Department of Medicine, Bernalillo County Medical Center, University of New Mexico School of Medicine, 87131, Albuquerque, New Mexico

    R. C. Williams Jr. & V. Raizada

  2. Rockefeller University, 20001, New York, New York

    I. Van de Rijn & J. B. Zabriskie

  3. Division of Rheumatology, Department of Medicine and the Howard Hughes Medical Institute, University of California, 90000, San Francisco, California

    J. D. Stobo

  4. ICMR/WHO Streptococcal Diseases Reference Laboratory, Department of Microbiology, Lady Hardinge Medical College, New Delhi, India

    K. Prakash & K. B. Sharma

Authors
  1. R. C. Williams Jr.
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  2. V. Raizada
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  3. K. Prakash
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  4. I. Van de Rijn
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  5. J. B. Zabriskie
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  6. J. D. Stobo
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  7. K. B. Sharma
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Williams, R.C., Raizada, V., Prakash, K. et al. Changes in T-lymphocyte subsets during acute rheumatic fever. J Clin Immunol 2, 166–172 (1982). https://doi.org/10.1007/BF00915218

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