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The plasmocytic reaction and immunological laws communication II. Immunological inhibition during immunization of rabbits with tetanus toxoid

  • Microbiology and Immunity
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

This investigation was devoted to the study of the inhibitory process in rabbits caused by repeated administration of tetanus toxoid. Investigations demonstrated that cytological changes develop in the regional lymphatic nodes of rabbits on repeated injection of the toxoid in sensitized animals. These changes are characterized by the accumulation of large cells of lymphoid type with a basophilic protoplasm (lymphoblasts or plasmoblasts). The serological examination of the extracts of these nodes shows the accumulation of large amounts of the antitoxin even in the early periods.

Numerous repeated revaccination with the toxoid causes a condition of immunological inhibition in rabbits, which is serologically manifested by the cessation of the rise of the antitoxin concentration in the regional nodes and later in its drop.

Morphologically this inhibition is manifested in the absence of the characteristic increase of the lymphoblasts in the lymph nodes. The effect of revaccination was strictly local. The content of antitoxin in the regional lymphatic nodes was low irrespective of the number of revaccinations.

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Authors and Affiliations

  1. Gamaleia Institute of Epidemiology and Microbiology of the AMN SSSR, USSR

    G. V. Shumakova & G. A. Gurvich

Authors
  1. G. V. Shumakova
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  2. G. A. Gurvich
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Shumakova, G.V., Gurvich, G.A. The plasmocytic reaction and immunological laws communication II. Immunological inhibition during immunization of rabbits with tetanus toxoid. Bull Exp Biol Med 46, 1350–1356 (1958). https://doi.org/10.1007/BF00845180

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  • DOI: https://doi.org/10.1007/BF00845180

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