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Action of di-iodobenzotepa on functionally different T-lymphocyte subpopulations

  • Microbiology and Immunology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Di-iodobenzotepa (DIB) was given per os daily for 3 days in a dose of 25 mg/kg to CBA mice. A decrease in the number of nucleated cells in the thymus by 74% and in the bone marrow by 29% was observed. Experiments with transplantation of lymphocytes from mice treated with DIB into intact or lethally irradiated (CBAxC57BL/6J)F1 mice showed that DIB has no effect on the helper activity of T-lymphocytes but depresses the functional activity of B-lymphocytes and t-lymphocytes, inducing the graft versus host reaction, and of T-suppressor cells.

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Authors and Affiliations

  1. Academy of Medical Sciences of the USSR, USSR

    R. V. Petrov

Authors
  1. G. N. Drannik
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  2. V. M. Man'ko
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  3. R. V. Petrov
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  4. P. Ya. Sologub
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  5. N. I. Sharykina
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Additional information

Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 88, No. 10, pp. 424–426, October, 1979.

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Drannik, G.N., Man'ko, V.M., Petrov, R.V. et al. Action of di-iodobenzotepa on functionally different T-lymphocyte subpopulations. Bull Exp Biol Med 88, 1141–1143 (1979). https://doi.org/10.1007/BF00838188

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  • DOI: https://doi.org/10.1007/BF00838188

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