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Inhibition of serotonin uptake by synaptosomes and glial cells induced by certain drugs

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Uptake of [14C]serotonin by glial cells and synaptosomes in the rabbit cerebral cortex was studied. The value of Km for serotonin uptake was the same (0.083±0.02 μM) for both synaptosomes and glial cells. Cortical synaptosomes took up serotonin twice as fast as glial cells (the rates of uptake were compared as protein). Of the psychotropic drugs tested, the most active inhibitors of both synaptosomal and glial serotonin uptake were the tricyclic antidepressant imipramine and the psychostimulant cocaine which, in concentrations of 50 μM, inhibited uptake of [14C]serotonin in synaptosomes by 90% and in glial cells by 75–80%.

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Authors
  1. T. A. Bakhanashvili
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  2. N. I. Maisov
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  3. A. D. Zharikova
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Bakhanashvili, T.A., Maisov, N.I. & Zharikova, A.D. Inhibition of serotonin uptake by synaptosomes and glial cells induced by certain drugs. Bull Exp Biol Med 88, 1299–1301 (1979). https://doi.org/10.1007/BF00835578

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  • DOI: https://doi.org/10.1007/BF00835578

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