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The neurochemical bases of the pharmacological activity of ligands of monoamine-transport systems

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Abstract

We review the transport systems of the monoamines dopamine, noradrenaline, and serotonin, which are localized in cytoplasmic membranes and the membranes of synaptic vesicles. We present information on the structure of the transporters and the mechanisms of their functioning. Ligands of the transport systems of monoamines include medications and drugs with psychostimulatory action. The most important neurochemical characteristics of ligands of monoamine transport systems is their affinity to transporters and the ability to inhibit reuptake of neuromediators or, in contrast, initiate a reverse current of neurotransmitters. This is the basis of the pharmacological activities of the considered substances.

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  1. Institute of Toxicology, Federal Medical-Biological Agency, St. Petersburg, Russia

    A. I. Golovko, E. Yu. Bonitenko, M. B. Ivanov, V. A. Barinov & E. P. Zatsepin

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  1. A. I. Golovko
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  2. E. Yu. Bonitenko
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  3. M. B. Ivanov
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Original Russian Text © A.I. Golovko, E.Yu. Bonitenko, M.B. Ivanov, V.A. Barinov, E.P. Zatsepin, 2016, published in Neirokhimiya, 2016, Vol. 33, No. 3, pp. 185–196.

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Golovko, A.I., Bonitenko, E.Y., Ivanov, M.B. et al. The neurochemical bases of the pharmacological activity of ligands of monoamine-transport systems. Neurochem. J. 10, 173–183 (2016). https://doi.org/10.1134/S1819712416030065

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