Abstract
The adenylate deaminase activity of the mitochondrial fraction of rat liver was stimulated in vivo not only by serotonin (5-HT) or other biogenic and synthetic indolylalkylamines, but also by phenyl- and imidazolealkylamines. 5-HT also stimulated adenylate deaminase activity of the liver mitochondria of CBA mice. Actinomycin D or cycloheximide, inhibitors of protein biosynthesis, prevented the stimulation of adenylate deaminase activity by 5-HT. Theophylline, a phosphodiesterase inhibitor, gave a similar effect only in the presence of a high degree of stimulation of adenylate deaminase activity.
Similar content being viewed by others
Literature Cited
L. I. Gridneva, N. N. Suvorov, and V. Z. Gorkin, Byull. Éksperim. Biol. Med., No. 7, 56 (1974).
O. P. Samarina, Dokl. Akad. Nauk SSSR,156, 1217 (1964).
K. Grahner and H. L. Segal, Biochim. Biophys. Acta,222, 508 (1970).
V. I. Kulinskii, Probl. Éndokrinol., No. 15, 67 (1970).
A. Guidotti and E. Costa, Science,179, 902 (1973).
A. G. Chapman and D. E. Atkinson, J. Biol. Chem.,248, 8309 (1973).
Rights and permissions
About this article
Cite this article
Gridneva, L.I., Repyakh, L.G., Suvorov, N.N. et al. Specificity and mechanism of stimulation of adenylate deaminase activity by serotonin. Bull Exp Biol Med 80, 1181–1183 (1975). https://doi.org/10.1007/BF00833153
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00833153