Abstract
Experiments on decerebrate cats revealed an inhibitory effect of γ-aminobutyric acid (GABA; 100–200 μg/kg) and its phenyl derivative, phenyl-GABA (20 mg/kg), on depressor responses of the systemic arterial pressure and on inhibition of spontaneous electrical activity in the renal nerve arising in response to excitation of the carotid sinus mechanoreceptors and afferent fibers on the sinus and depressor nerves carrying impulses from mechanoreceptors. Pressor responses of the systemic arterial pressure and electrical activity evoked in the renal nerve by stimulation of the carotid sinus chemoreceptors were intensified after administration of the same doses of GABA and phenyl-GABA. The results are interpreted from the standpoint of the depriming action of GABA and its phenyl derivative on the paramedian reticular nuclei of the medulla.
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Additional information
Paper read at the March, 1974 Meeting of the Volgograd Scientific Society of Pharmacologists.
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Kovalev, G.V., Morozov, I.S. Action ofγ-aminobutyric acid and its phenyl derivative on central links of vascular reflexes from aortic-carotid chemo- and mechanoreptors. Bull Exp Biol Med 79, 421–424 (1975). https://doi.org/10.1007/BF00832715
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DOI: https://doi.org/10.1007/BF00832715