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Content of nicotinamide coenzymes in the liver and myocardium of rats poisoned with dichloroethane

  • Biochemistry and Biophysics
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The content of nicotinamide coenzymes in the liver and myocardium was studied in experiments on male rats 24 h after dichloroethane poisoning (0.5 ml/kg by the intragastric route). Parallel with disturbance of the morphological structure of the liver and myocardium and an increase in alanine and asparagine aminotransferase activity in the blood serum, dichloroethane was shown to reduce the concentration of nicotinamide coenzymes and to disturb the ratio between their oxidized and reduced forms in these organs.

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Literature Cited

  1. V. V. Lyakhovich, A. V. Dolgov, V. M. Mishin, et al., Farmakol. i Toksikol. No. 2, 243 (1972).

    Google Scholar 

  2. V. V. Men'shikov, in: Unified Methods of Clinical Laboratory Investigation [in Russian], No. 1, Moscow (1970), p. 15.

  3. G. N. Morozov, Farmakol. i Toksikol., No. 1, 76 (1958).

    Google Scholar 

  4. M. V. Natsyuk, F. S. Chernukha, G. A. Basenko, et al., Farmakol. i Toksikol., No. 1 92 (1974).

    Google Scholar 

  5. V. L. Nemchinskaya, V. M. Bozhkov, and V. P. Kushner, Tsitologiya, No. 7, 799 (1971).

    Google Scholar 

  6. C. A. Rubchevskii, “Results of a study of the clinical picture and treatment of acute dichloroethane poisoning,” Author's Abstract of Candidate's Dissertation, Kuibyshev (1962).

  7. L. A. Tseitlin, Uspekhi Biol. Khimii,8, 249 (1967).

    Google Scholar 

  8. E. F. Shamrai and A. K. Selezneva, Vopr. Med. Khimii, No. 5, 512 (1969).

    Google Scholar 

  9. F. S. Chernukha, in: Pharmacology and Toxicology [in Russian], No. 8, Kiev (1973), p. 148.

  10. V. A. Shkurupii, Byull. Éksperim. Biol. i Med., No. 2, 110 (1973).

    Google Scholar 

  11. A. Francavilla, O. Albano, B. Meduri, et al., Clin. Chim. Acta.,30, 415 (1970).

    Google Scholar 

  12. I. W. Huff, J. Biol. Chem.,167, 157 (1947).

    Google Scholar 

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Natsyuk, M.V., Chekman, I.S. Content of nicotinamide coenzymes in the liver and myocardium of rats poisoned with dichloroethane. Bull Exp Biol Med 79, 408–409 (1975). https://doi.org/10.1007/BF00832711

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  • DOI: https://doi.org/10.1007/BF00832711

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