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The role of acetylcholine in the development of tetanic single response and afterpotentials in the nerve trunk of cold-blooded animals

  • Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Experiments were performed on the nerve trunks of frogs in which the production of acetylcholine was disturbed by removal of the pancreas. This brought about an increase of the negative afterpotential and prologation of tetanized single response on the 4th to 10th day following the operation. The compensatory administration of acetylcholine removed these changes in the majority of cases. Preliminary administration of eserine to normal frogs resulted in decrease of the negative afterpotential. With administration of eserine the conditions for appearance of the tetanized single response deteriorated. Evidently, acetylcholine promotes the decrease of the duration of residual processes of excitation in the nerve tissue.

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Authors and Affiliations

  1. Department of Normal Physiology, Kazan Medical Institute, Kazan, USSR

    G. I. Poletaev

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  1. G. I. Poletaev
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Poletaev, G.I. The role of acetylcholine in the development of tetanic single response and afterpotentials in the nerve trunk of cold-blooded animals. Bull Exp Biol Med 45, 670–673 (1958). https://doi.org/10.1007/BF00824581

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  • DOI: https://doi.org/10.1007/BF00824581

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