Summary
Experiments were performed on cats under urethan anesthesia and on cats with normal respiration.
Pericardial receptors stimulated by nicotine (0.4·10−9 to 1·10−3) cause pronounced reflex changes in the level of the blood pressure, heart rate and respiration. In 60% of experiments, stimulation of pericardial receptors by weak concentrations of nicotine caused increase of the blood pressure and tachycardia, while stimulation by strong concentrations of nicotine resulted in reflex decrease of the blood pressure and bradycardia. In 25% of the experiments, the animals reacted by pressor reactions and tachycardia when pericardial receptors were stimulated [by any concentration of nicotine. In 15% of the experiments, any stimulation of these receptors by nicotine caused depression of the cardiovascular system. In all experiments, any chemical stimulation of pericardial receptors both by weak and strong solutions caused increase of the rate and depth of respiratory movements.
It is suggested that the change of the pressor reaction into depressor is caused not by the stimulation of different types of receptors, but depends on the more intense stimulation of a large number of similar receptors.
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Kulaev, B.S. Reflex changes in the activity of the cardiovascular system under the influence of chemical stimulation of pericardial receptors. Bull Exp Biol Med 45, 662–666 (1958). https://doi.org/10.1007/BF00824579
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DOI: https://doi.org/10.1007/BF00824579