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Ferrocene derivatives, Part 69 Preparative separation of isomeric trisubstituted ferrocenes

Präparative Isomerentrennung von trisubstituierten Ferrocenen. 69. Mitt. über Ferrocenderivate

  • Organische Chemie Und Biochemie
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Summary

Mixtures of positional isomers of trisubstituted ferrocenes can conveniently be separated on a preparative scale by applying medium-pressure liquid chromatography to suitable intermediates. By this technique formyl, hydroxymethyl, and dimethylaminomethyl 1,2-dimethyl-and 1,2-tetramethylene ferrocene, resp., (2, 3, 4 and6, 7, 8, resp.) were prepared as pure isomers (on a gramscale) by appropriate interconversion and chromatographic separation steps.

Zusammenfassung

Mischungen von stellungsisomeren, trisubstituierten Ferrocenen können auch im präparativen Maßstab unter Anwendung der Mitteldruckchromatographie auf geeignete Zwischenprodukte glatt getrennt werden. Mit Hilfe dieser Technik wurden Formyl-, Hydroxymethyl- und Dimethylaminomethyl-1,2-dimethyl- bzw. 1,2-tetramethylen-ferrocen (2, 3, 4 bzw.6, 7, 8) durch Anwendung geeigneter Umwandlungs- und Chromatographie-Schritte im Grammaßstab isomerenrein erhalten.

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Authors and Affiliations

  1. Institut für Organische Chemie, Universität Wien, A-1090, Wien, Österreich

    Paul Krajnik, Karl Schlögl & Michael Widhalm

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  1. Paul Krajnik
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  2. Karl Schlögl
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  3. Michael Widhalm
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Krajnik, P., Schlögl, K. & Widhalm, M. Ferrocene derivatives, Part 69 Preparative separation of isomeric trisubstituted ferrocenes. Monatsh Chem 121, 413–419 (1990). https://doi.org/10.1007/BF00809458

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  • DOI: https://doi.org/10.1007/BF00809458

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