Abstract
The effect of influenza A (PR8/34) virus and its structural components on immunologic reactivity was studied in mice. Neuraminidase, the enzyme of the influenza virus outer membrane, possesses an immunodepressive action. The addition of neuraminidase leads to removal of sialic acids from the surface of the lymphocytes and reduces their electrophoretic mobility. The mechanism of the immunodepressive action of neuraminidase is discussed.
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Literature Cited
L. A. Pevnitskii, V. V. Solov'ev, and L. N. Fontalin, Byull. Éksp. Biol. Med., No. 8, 85 (1965).
L. V. Yakimenko, Z. D. Savtsova, S. L. Rybalko, et al., Vopr. Virusol., No. 1, 96, (1975).
H. A. Abramson, L. S. Moyer, and M. H. Gorin, Electrophoresis of Proteins, New York (1942), pp. 126–128.
R. C. Hughes, P. D. Palmer, and B. H. Sandford, J. Immunol.,111, 1071 (1973).
P. Isaacson, Prog. Allergy,10, 256 (1976).
N. K. Jerne and A. A. Nordin, Science,140, 405 (1963).
W. G. Laver and K. C. Valentine, Virology,38, 105 (1969).
G. N. Rogentine and B. A. Plocinic, J. Immunol.,113, 848 (1974).
G. Warren, J. Biol. Chem.,237, 1971 (1959).
G. Weiss, J. Natl. Cancer Inst.,50, 3 (1973).
J. J. Woodruff and J. F. Woodruff, J. Immunol.,117, 859 (1975).
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Laboratory of Virus Carcinogenesis, Department of General Mechanisms of Carcinogenesis, Institute for Problems in Oncology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 85, No. 5, pp. 547–549, May, 1978.
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Novichenko, N.L., Struk, V.I. & Kavetskii, R.E. Effect of influenza virus and its structural components on the immunocompetent system of animals. Bull Exp Biol Med 85, 595–598 (1978). https://doi.org/10.1007/BF00806381
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DOI: https://doi.org/10.1007/BF00806381