Abstract
Treatment of bone marrow with serum reacting with theta-antigen, irrespective of the presence of complement, sharply reduces the ability of its cells to form splenic colonies. Injection of thymus cells into the recipient together with bone marrow cells considerably reduces the effect of this serum and substantially increases splenic colony formation. It is suggested that the antiserum inactivates a cell population in the bone marrow that is essential for colony formation in the spleen, but which differs from the pluripotent stem cells-probably the T cell population
Similar content being viewed by others
Literature Cited
A. M. Poverennyi, O. V. Semina, and A. G. Konoplyannikov, Dokl. Akad. Nauk SSSR,223, 1248 (1975).
E. S. Golub, Cell Immunol.,2, 353 (1971).
B. I. Lord and R. Schofield, Blood,42, 395 (1973).
M. Rosendaal, Nature,265, 147 (1977).
J. Till and E. McCulloch, Radiat. Res.,14, 213 (1961).
J. G. Van den Engh and E. S. Golub, J. Exp. Med.,139, 1621 (1974).
Rights and permissions
About this article
Cite this article
Poverennyi, A.M., Semina, O.V., Semenets, T.N. et al. Role of thymus-dependent cells in splenic colony formation. Bull Exp Biol Med 85, 774–775 (1978). https://doi.org/10.1007/BF00806162
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00806162