Morphological changes in the thymus of female Wistar rats with experimental mammary gland carcinomas were studied. After adjuvant therapy, the area of the cortical matter and density of parenchymal cells in the thymus decreased, while areas of the medulla, connective tissue, and content of immunoblasts and macrophages increased. In the thymuses of rats receiving exogenous DNA, morphological signs of activation of the lymphoid and epithelial components were found: areas of the cortex and medulla, glandular and connective tissue corresponded to the values in intact animals, the counts of lymphocytes in the central part of the cortical matter and of macrophages in all zones of the thymus increased, and lymphocyte migration from the thymus increased (in comparison with the chemotherapy group).
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Gvozdeva TS, Proskurina AS, Orishchenko KE, Sidorov SV, Chernykh ER, Ostanin AA, Leplina OYu, Dvornichenko VV, Ponomarenko DM, Soldatova GS, Varaksin NA, Ryabicheva TG, Zagrebelnij SN, Nikolin VP, Popova NA, Rogachev VA, Alyamkina EA, Dolgova EV, Bogachev SS, Shurdov MA. Leykostimulatory and antitumor effect of the human doublestranded DNA preparation “Panagen” in experiments and clinical trials. II. Leykostimulatory and antitumor effect of the preparation “Panagen” in clinical trials. Vestn. Novosibirsk. Gos. Univer. Ser. Biol., Klin. Med. 2013;11(4):83-90. Russian.
Drandrova EG, Struchko GYu, Merkulova LM, Kostrova OYu, Moskvichev EV, Mikhaylova MN, Arlashkina OM. Immunohistochemical researches of thymic cellular composition at carcinogenesis in condition of congenital immunodeficiency. Sovremen. Probl. Nauki Obrazov. 2015;(3):193. [URL: http://www.science-education.ru/pdf/2015/3/405.pdf]. Russian.
Kazakov OV, Kabakov AV, Poveschenko AF, Miller TV, Chepik VI, Rajter TV, Strunkin DN, Larionov PM, Konenkov VI. Thymus in mammary gland experimental carcinogenesis. Vestn. Novosibirsk. Gos. Univer. Ser. Biol., Klin. Med. 2014;12(3):58-62. Russian.
Kiseleva EP. Mechanisms of thymic involution in tumor growth. Uspekhi Sovremen. Biol. 2004;124(6):589-601. Russian.
Koveshnikov VG, Bibik EYu. Functional Morphology of Immune System Organs. Lugansk, 2007. Russian.
Nikolin VP, Popova NA, Sebeleva TYe, Strounkin DN, Rogachev VA, Semenov DV, Bogachev SS, Yakubov LA, Shurdov MA. Effect of exogenous DNA injection on leukopoietic repair and antitumor action of cyclophosphamide. Vopr. Onkol. 2006;52(3):336-340. Russian.
Poveschenko AF, Kazakov OV, Orlov NB, Poveschenko OV, Kim II, Bondarenko NA, Miller TV, Soloveva IG, Strunkin DN, Kabakov AV, Rayter TV, Lykov AP, Rogachev VA, Bogachev SS, Konenkov VI. Serum cytokines of Wistar rats –markers of carcinogenesis and effectiveness of cancer therapy. Fundamental. Issled. 2015;(1-8):1664-1670. Russian.
Proskurina AS, Alyamkina EA, Dolgova EV, Nikolin VP, Popova NA, Gvozdeva TS, Orishchenko KE, Sidorov SV, Chernykh ER, Ostanin AA, Leplina OYu, Dvornichenko VV, Ponomarenko DM, Soldatova GS, Varaksin NA, Ryabicheva TG, Zagrebelnij SN, Rogachev VA, Bogachev SS, Shurdov MA. Leykostimulatory and antitumor effect of the human double-stranded dna preparation “Panagen” in experiments and clinical trials. I. Leykostimulatory and antitumor effect of the preparation “Panagen” in experiments. Vestn. Novosibirsk. Gos. Med. Univer. Ser. Biol., Klin. Med. 2013;11(4):67-82. Russian.
Sarkisov DS, Perov YuL. Microscopic Techniques: Manual for Physicians and Technicians. Moscow, 1996. Russian.
Cheknev SB. Natural cytotoxicity in the complex of cell-cell interactions. Vestn. Ross. Akad. Med. Nauk. 1999;(4):30-34. Russian.
Alyamkina EA, Leplina OY, Sakhno LV, Chernykh ER, Ostanin AA, Efremov YR, Shilov AG, Proskurina AS, Orishchenko KE, Dolgova EV, Rogachev VA, Nikolin VP, Popova NA, Zagrebelniy SN, Bogachev SS, Shurdov MA. Effect of double-stranded DNA on maturation of dendritic cells in vitro. Cell. Immunol. 2010;266(1):46-51.
Freyer G, Braud AC, Chaibi P, Spielmann M, Martin JP, Vilela G, Guerin D, Zelek L. Dealing with metastatic breast cancer in elderly women: results from a French study on a large cohort carried out by the ‘Observatory on Elderly Patients’. Ann. Oncol. 2006;17(2):211-216.
Wildiers H, Kunkler I, Biganzoli L, Fracheboud J, Vlastos G, Bernard-Marty C, Hurria A, Extermann M, Girre V, Brain E, Audisio RA, Bartelink H, Barton M, Giordano SH, Muss H, Aapro M; International Society of Geriatric Oncology. Management of breast cancer in elderly individuals: recommendations of the International Society of Geriatric Oncology. The Lancet Oncology. 2007;8(12):1101-1115.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 11, pp. 607-611, November, 2016
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Kazakov, O.V., Kabakov, A.V., Poveshchenko, A.F. et al. Changes in the Structure of the Thymus under Conditions of Various Treatments for Experimental Mammary Tumor. Bull Exp Biol Med 162, 654–657 (2017). https://doi.org/10.1007/s10517-017-3680-7
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DOI: https://doi.org/10.1007/s10517-017-3680-7