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Intensity of synthesis of phospholipids and cholesterol in the brain and spinal cord of rabbits with experimental allergic encephalomyelitis

  • Biochemistry and Biophysics
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Experimental allergic encephalomyelitis (EAE) was induced in rabbits by inoculation of homologous spinal cord myelin. In the terminal state of the disease acetate-2-C14 was injected in a dose of 50 μCi/100 g body weight and the animals were killed 2 h later. The intensity of synthesis of phospholipids and cholesterol was greatly reduced in EAE not only in the lumbar region of the spinal cord, where the injury to myelin was greatest, but also in the brain stem, where demyelinization was absent.

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Authors
  1. N. N. Taranova
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  2. I. P. Katsnel'son
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Taranova, N.N., Katsnel'son, I.P. Intensity of synthesis of phospholipids and cholesterol in the brain and spinal cord of rabbits with experimental allergic encephalomyelitis. Bull Exp Biol Med 81, 334–337 (1976). https://doi.org/10.1007/BF00804911

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  • DOI: https://doi.org/10.1007/BF00804911

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