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Activity of Antioxidant Defense Enzymes in Rats with Experimental Allergic Encephalomyelitis

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We studied activities of antioxidant system enzymes in tissues of rats with experimental allergic encephalomyelitis. It was shown that the development of pathology is accompanied by deformation of the neurons and axonal degeneration, intensification of free radical oxidation, exhaustion of the reduced glutathione pool, and multidirectional changes in activities of antioxidant enzymes in rat tissues. The observed imbalance in the antioxidant defense system can be associated with excessive glutathione utilization in the glutathione transferase reaction and different severity of the pathological process in the brain and spinal cord. The received data necessitate the search for compounds that can prevent inhibition of antioxidant system components in order to analyze the possibility of their use in the treatment of multiple sclerosis.

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References

  1. Afanasiev VG, Zaitsev VS, Volfson TI. A micromethod of determination of citric acid in the blood serum by means of a photoelectrocolorimeter. Lab. Delo. 1973;2:115-6. Russian.

    CAS  PubMed  Google Scholar 

  2. Glantz SA. Primer of Biostatistics. Moscow, 1999. Russian.

  3. Mamykova OI. Methodological provisions for quantitative determination and qualitative analysis of circulating immune complexes in the blood serum of animals in diseases of invasive etiology. Ross. Parazitol. Zh. 2013;(3):127-129. Russian.

    Google Scholar 

  4. Adamczyk B, Adamczyk-Sowa M. New Insights into the Role of Oxidative Stress Mechanisms in the Pathophysiology and Treatment of Multiple Sclerosis. Oxid. Med. Cell. Longev. 2016;2016. 1973834.

  5. Chiurchiù V, Orlacchio A, Maccarrone M. Is Modulation of Oxidative Stress an Answer? The State of the Art of Redox Therapeutic Actions in Neurodegenerative Diseases. Oxid. Med. Cell. Longev. 2016;2016. 7909380. https://doi.org/10.1155/2016/7909380

  6. Fitzpatrick AM, Jones DP, Brown LA. Glutathione redox control of asthma: from molecular mechanisms to therapeutic opportunities. Antioxid. Redox Signal. 2012;17(2):375-408. https://doi.org/10.1089/ars.2011.4198

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Hadžović-Džuvo A, Lepara O, Valjevac A, Avdagić N, Hasić S, Kiseljaković E, Ibragić S, Alajbegović A. Serum total antioxidant capacity in patients with multiple sclerosis. Bosn. J. Basic Med. Sci. 2011;11(1):33-36.

    Article  Google Scholar 

  8. Kryl’skii ED, Popova TN, Safonova OA, Stolyarova AO, Razuvaev GA, de Carvalho MAP. Transcriptional Regulation of Antioxidant Enzymes Activity and Modulation of Oxidative Stress by Melatonin in Rats Under Cerebral Ischemia / Reperfusion Conditions. Neuroscience. 2019;406:653-666.

    Article  Google Scholar 

  9. Machado-Santos J, Saji E, Tröscher AR, Paunovic M, Liblau R, Gabriely G, Bien CG, Bauer J, Lassmann H. The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells. Brain. 2018;141(7):2066-2082.

    Article  Google Scholar 

  10. Ortiz GG, Pacheco-Moisés FP, Bitzer-Quintero OK, Ramírez-Anguiano AC, Flores-Alvarado LJ, Ramírez-Ramírez V, Macias-Islas MA, Torres-Sánchez ED. Immunology and oxidative stress in multiple sclerosis: clinical and basic approach. Clin. Dev. Immunol. 2013;2013. 708659. https://doi.org/10.1155/2013/708659

  11. Rajda C, Pukoli D, Bende Z, Majláth Z, Vécsei L. Excitotoxins, Mitochondrial and Redox Disturbances in Multiple Sclerosis. Int. J. Mol. Sci. 2017;18(2). https://doi.org/10.3390/ijms18020353

  12. Ringheim GE, Lee L, Laws-Ricker L, Delohery T, Liu L, Zhang D, Colletti N, Soos TJ, Schroeder K, Fanelli B, Tian N, Arendt CW, Iglesias-Bregna D, Petty M, Ji Z, Qian G, Gaur R, Weinstock D, Cavallo J, Telsinskas J, McMonagle-Strucko K. Teriflunomide attenuates immunopathological changes in the dark agouti rat model of experimental autoimmune encephalomyelitis. Front. Neurol. 2013;4:169. https://doi.org/10.3389/fneur.2013.00169

    Article  PubMed  PubMed Central  Google Scholar 

  13. Smerjac SM, Bizzozero OA. Cytoskeletal protein carbonylation and degradation in experimental autoimmune encephalomyelitis. J. Neurochem. 2008;105(3):763-772.

    Article  CAS  Google Scholar 

  14. Tian KW, Zhang F, Jiang H, Wang B, Han S. Role of C16, angio-poietin-1 and regeneration gene protein 2 in attenuating inflammation in an experimental rat model of autoimmune encephalomyelitis. J. Anat. 2017;230(1):30-46. https://doi.org/10.1111/joa.12541

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Medical Biochemistry and Microbiology, Voronezh State University, Voronezh, Russia

    E. D. Kryl’skii, T. N. Popova, G. A. Razuvaev, T. A. Aksinina & A. V. Ryapolova

  2. Department of Human and Animal Physiology, Medical and Biological Faculty, Voronezh State University, Voronezh, Russia

    N. D. Polyakova-Semenova & G. A. Vashanov

Authors
  1. E. D. Kryl’skii
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  2. T. N. Popova
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  3. N. D. Polyakova-Semenova
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  4. G. A. Vashanov
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  5. G. A. Razuvaev
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  6. T. A. Aksinina
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  7. A. V. Ryapolova
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Corresponding author

Correspondence to E. D. Kryl’skii.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 168, No. 12, pp. 722-727, December, 2019

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Kryl’skii, E.D., Popova, T.N., Polyakova-Semenova, N.D. et al. Activity of Antioxidant Defense Enzymes in Rats with Experimental Allergic Encephalomyelitis. Bull Exp Biol Med 168, 761–766 (2020). https://doi.org/10.1007/s10517-020-04797-7

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  • DOI: https://doi.org/10.1007/s10517-020-04797-7

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