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Activation of respiration of liver mitochondria in various metabolic states by cyclic 3′,5′-AMP

  • Biochemistry and Biophysics
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Cyclic 3′,5′-AMP (10−6M) activates respiration of the liver mitochondria in all metabolic states and neither changes nor increases the rate of phosphorylation during oxidation of saturating concentrations of isocitrate and succinate. For the effect to be manifested, preincubation of the mitochondria or liver homogenate with cyclic AMP is necessary. The fifth fraction of serum albumin and EDTA do not abolish the effect. Noradrenalin (NA) increases mitochondrial respiration only on incubation with the homogenate. Effects of NA and cyclic AMP do not undergo summation, and the effect of the former is probably mediated by cyclic AMP. The results do not confirm the decisive role of uncoupling of respiration and phosphorylation or accumulation of the oxidation substrate, but instead they suggest activation of mitochondrial enzymes.

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Authors
  1. V. I. Kulinskii
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  2. L. M. Vorob'eva
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Kulinskii, V.I., Vorob'eva, L.M. Activation of respiration of liver mitochondria in various metabolic states by cyclic 3′,5′-AMP. Bull Exp Biol Med 85, 306–308 (1978). https://doi.org/10.1007/BF00801342

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  • DOI: https://doi.org/10.1007/BF00801342

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