Abstract
The action of x-ray irradiation on DNA synthesis in the epithelium of the uterine glands of ovariectomized mice stimulated by dihydrostilbestrol and the dependence of its action on the phase of the mitotic cycle were studied by autoradiography with thymidine-3H. After local irradiation of the region of the uterus in a dose of 400 rad the decrease in the index of labeled nuclei was found to differ depending on the phase of the mitotic cycle in which most cells were.
Similar content being viewed by others
Literature Cited
V. M. Budik, “Cytochemical and autoradiographic detection of nucleic acids in connection with the proliferative activity of the epithelium of the uterus and vagina,” Author's Abstract of Candidate's Dissertation, Moscow (1970).
S. I. Mkrtchyan, Byull. Éksp. Biol. Med., No. 11, 96 (1973).
N. A. Roslyakova, Byull. Éksp. Biol. Med., No. 10, 92 (1970).
I. Ionek, L. Klimkiewicz, and I. Konecki, Ginekol. Pol.,41, 375 (1970).
L. Klimkiewicz, I. Ionek, and I. Konecki, Ginekol. Pol.,45, 527 (1974).
L. Y. Ladinsky and H. W. Gichow, Cell Tissue Kinet.,3, 175 (1970).
C. A. Perotta, Am. J. Anat.,111, 195 (1962).
C. A. Perotta, Radiat. Res.,28, 232 (1966).
Rights and permissions
About this article
Cite this article
Ogandzhanyan, É.E., Mkrtchyan, S.A. Action of X-ray radiation on DNA synthesis in the epithelium of the uterine glands and its dependence on the phase of the mitotic cycle. Bull Exp Biol Med 83, 695–697 (1977). https://doi.org/10.1007/BF00800753
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00800753