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The Dependence of the Mutagenic Effect on the Dose of X-Ray Irradiation in an In Vivo Experiment on Female (CBA×C57Bl/6)F1 Mice

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We studied the mutagenic effect of X-ray irradiation in doses of 0.5, 1, and 1.5 Gy on female (CBA×C57Bl/6)F1 mice. The mutagenic effect (assessed by the parameter “frequency of bone marrow polychromatophilic erythrocytes with micronuclei”) linearly depended on the dose of X-ray irradiation in the range of up to 1 Gy and reached the plateau at 1.5 Gy. The fraction of polychromatophilic erythrocytes was 45, 45, and 46% under control conditions (without exposure) and exposure to the irradiation in the doses of 0.5 and 1 Gy, respectively. Irradiation in a dose of 1.5 Gy induced a slight inhibition of erythropoiesis. These data confirm the hypothesis on possible death of highly aberrant erythrocyte precursors after irradiation in high doses.

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Authors and Affiliations

  1. A. I. Burnazyan Federal Medical Biophisical Center, Federal Medical and Biological Agency of the Moscow, Moscow, Russia

    L. P. Sycheva, R. A. Shchegoleva, N. I. Lisina, A. V. Gordeev & L. M. Rozhdestvenskii

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  1. L. P. Sycheva
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  2. R. A. Shchegoleva
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  3. N. I. Lisina
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  4. A. V. Gordeev
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  5. L. M. Rozhdestvenskii
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Correspondence to L. P. Sycheva.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 166, No. 7, pp. 50-52, July, 2018

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Sycheva, L.P., Shchegoleva, R.A., Lisina, N.I. et al. The Dependence of the Mutagenic Effect on the Dose of X-Ray Irradiation in an In Vivo Experiment on Female (CBA×C57Bl/6)F1 Mice. Bull Exp Biol Med 166, 43–45 (2018). https://doi.org/10.1007/s10517-018-4285-5

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  • DOI: https://doi.org/10.1007/s10517-018-4285-5

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