Abstract
Antibody formation against sheep's red cells and human serum albumin took place with the same intensity in rabbits with alimentary atherosclerosis as in normal animals. Trasylol did not affect antibody formation in healthy animals but sharply inhibited the formation of specific immunoglobulins (especially 7S) in rabbits with experimental atherosclerosis. This suggests that trasylol acts not by directly inhibiting the function of lymphoid tissue cells, but by inhibiting an immunostimulant factor that circulates in the blood stream in experimental atherosclerosis.
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Literature Cited
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Prokopenko, L.G., Drobyazgo, L.D. Effect of the polyvalent proteinase inhibitor trasylol on antibody formation under normal conditions and in experimental atherosclerosis. Bull Exp Biol Med 79, 558–559 (1975). https://doi.org/10.1007/BF00800502
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DOI: https://doi.org/10.1007/BF00800502