Abstract
Age differences in interaction between the hypothalamic-hypophyseal system and the thyroid gland were studied with consideration to both direct and feedback control. In old age significant disturbances affect both direct and feedback components of this system; the sensitivity of thyroid tissue to TSH and of the hypothalamus and pituitary to the action of T4 is increased. The increased sensitivity of the hypothalamic-hypophyseal system to T4 is largely determined by activation of the deiodination of T4 by the adenohypophysis. The reactivity of the thyroid gland and hypothalamic-hypophyseal complex to the corresponding factors is reduced.
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Frol'kis, V.V., Valueva, G.V. & Verzhikovskaya, N.V. Interaction between the hypothalamic-hypophyseal system and thyroid gland at different age periods. Bull Exp Biol Med 86, 981–984 (1978). https://doi.org/10.1007/BF00799567
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DOI: https://doi.org/10.1007/BF00799567