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Individual Features of the Hypothalamic—Pituitary—Thyroid Axis Functioning during Aging in Non-Human Primates

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Individual features of age-related changes in the function of the neuroendocrine systems are an important problem as the basic component of a personalized approach to predicting and treating age-related pathologies. We studied the age-related features of the function of the hypothalamic—pituitary—thyroid axis in laboratory primates with depression- and anxiety-like behavior (DAB). It was found that in young female rhesus monkeys with DAB, the basal and thyrotropin-releasing hormone-stimulated levels of thyroid-stimulating hormone were significantly lower than in young animals with standard behavior (control). During aging, the levels of thyroid-stimulating hormone increased in DAB animals and free thyroxine concentrations decreased both at baseline (fasting) and in response to the thyrotropin-releasing hormone test, while in animals with standard behavior, only a trend towards similar hormonal changes was revealed.

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Authors and Affiliations

  1. Laboratory of Experimental Endocrinology, Research Institute of Medical Primatology, Sochi, Russia

    N. D. Goncharova, A. M. Ermolaeva, O. A. Chigarova, T. E. Oganyan, L. G. Ivanova & N. V. Timoshenko

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  1. N. D. Goncharova
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  2. A. M. Ermolaeva
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  3. O. A. Chigarova
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  4. T. E. Oganyan
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  5. L. G. Ivanova
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  6. N. V. Timoshenko
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Corresponding author

Correspondence to N. D. Goncharova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 4, pp. 500-505, April, 2023

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Goncharova, N.D., Ermolaeva, A.M., Chigarova, O.A. et al. Individual Features of the Hypothalamic—Pituitary—Thyroid Axis Functioning during Aging in Non-Human Primates. Bull Exp Biol Med 175, 497–502 (2023). https://doi.org/10.1007/s10517-023-05894-z

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  • DOI: https://doi.org/10.1007/s10517-023-05894-z

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