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Pharmacokinetics of ftorafur-2-14C in rats with Walker's carcinosarcoma

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The pharmacokinetics of ftorafur-2-14C (FF) after intravenous injection was investigated in experiments on rats with Walker's carcinosarcoma. The level of FF and its metabolites in the blood plasma was shown to fall in the manner of a three-phase process. The concentration of the compound in the tissues falls in the order: kidneys, small intestine, tumor, stomach, muscles, heart, liver, lungs, spleen, brain, and fat. The presence of FF-2-14C and its metabolite, endogenous 5-fluorouracil, was observed in the tumor. Excretion of the compound continued for 48 h, 52.2% being excreted through the kidneys, 38% through the lungs, and 0.8% of the injected dose with the feces.

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Authors
  1. A. N. Kozhukhov
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  2. D. V. Meiren
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  3. A. P. Gilev
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Kozhukhov, A.N., Meiren, D.V. & Gilev, A.P. Pharmacokinetics of ftorafur-2-14C in rats with Walker's carcinosarcoma. Bull Exp Biol Med 83, 872–875 (1977). https://doi.org/10.1007/BF00798902

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  • DOI: https://doi.org/10.1007/BF00798902

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