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Biosynthesis of proteins of the blood serum, liver, and aorta in experimental atherosclerosis

  • Biochemistry and Biophysics
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Labelled glycine-1-C14 and methionine-1-C14 were used to study the biosynthesis of protein fractions of the blood serum, proteins of the subcellular fractions of the liver and fractions of aorta proteins in rabbits with experimental cholesterol atherosclerosis. It has been found that in atherosclerosis there is an unequal decrease in the biosynthesis of all protein fractions of the blood serum. The decrease in the biosynthesis of liver proteins in experimental atherosclerosis is due to a decrease in protein synthesis in nuclear and microsome fractions of the liver cell. In experimental atherosclerosis there is a decrease in the synthesis of collagen and no change in the biosynthesis of soluble proteins and elastin of the aorta.

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Authors and Affiliations

  1. Institute of Therapy, Academy of Medical Sciences of the USSR, Moscow

    B. S. Sukhareva, P. Ts. Pavlova & V. F. Zaitsev

Authors
  1. B. S. Sukhareva
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  2. P. Ts. Pavlova
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  3. V. F. Zaitsev
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Sukhareva, B.S., Pavlova, P.T. & Zaitsev, V.F. Biosynthesis of proteins of the blood serum, liver, and aorta in experimental atherosclerosis. Bull Exp Biol Med 62, 1130–1132 (1966). https://doi.org/10.1007/BF00795457

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  • DOI: https://doi.org/10.1007/BF00795457

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