Abstract
The effect of sodium hydroxybutyrate (40, 100, and 200 mg/kg) on the cirulation in the aorta and the carotid, mesenteric, and femoral arteries (using electromagnetic recording of the blood flow), the tonic activity in the sympathetic nerves, and the EEG was studied in experiments on anesthetized and unanesthetized cats and also on immobilized, unanesthetized dogs. Decreased activity of the sympathetic nerves and synchronization of the EEG under the influence of sodium hydroxybutyrate were found to be associated with a marked increase in the circulation in the regional vessels (of the brain, intestine, and limb) and by a decrease in their resistance, which was particularly marked in the system of the common carotid arteries. An effect of sodium hydroxybutyrate on the central regulation of vascular tone is postulated.
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Literature Cited
É. A. Bendikov, L. M. Shmuilovich, and V. M. Kopelevich, “Effect of α-aminobutyric acid, nicotinoyl-α-aminobutyric acid, and its ethyl ester on central processes of formation of vasomotor reflexes,” Byull. Éksperim. Biol. i Med., No. 1, 65 (1972).
V. G. Butuzov and É. A. Bendikov, “On the central mechanisms determining the character of the effects of catecholamines on sympathetic tone and vasomotor reflexes,” Farmakol. i Toksikol., No. 5, 533 (1969).
N. B. Vysotskaya, V. V. Zakusov, and Z. N. Chumina, “Effect of sodium hydroxybutyrate on oxidate processes in the brain,” Farmakol. i Toksikol., No. 5, 515 (1970).
V. V. Zakusov (editor), Sodium Hydroxybutyrate [in Russian], Meditsina, Moscow (1968).
V. V. Zakusov, Pharmacology of Central Synapses [in Russian], Meditsina, Moscow (1973).
V. V. Zakusov, R. U. Ostrovskaya, A. M. Zubovskaya, et al., “Experimental and clinical studies of the protective effect of GABA derivatives in hypoxia,” Abstracts of Proceedings of the Plenum of the Council of the All-Union Scientific Society of Pharmacologists on the Problem of Pharmacotherapy [in Russian], Kishinev (1974), pp. 3–5.
A. Laborit, Regulation of Metabolic Processes [Russian translation], Meditsina, Moscow (1970).
S. A. Mirzoyan, B. A. Kazaryan, and V. P. Akopyan, “Effect of neuroactive amino acids on the circulation in various structures of the brain and amino acid metabolism in the walls of its arteries,” in: Current Problems in Pharmacology [in Russian], Kiev (1971), pp. 184–185.
R. U. Ostrovskaya, V. Yu. Ostrovskii, and E. L. Geselevich, “The effect of sodium hydroxybutyrate on the content of lactic and pyruvic acids in hypoxia,” Byull. Éksperim. Biol. i Med., No. 1, 36 (1969).
A. E. Uspenskii and L. A. Serebryakov, Sodium Hydroxybutyrate [in Russian], Moscow (1974).
V. M. Khayutin, Vasomotor Reflexes [in Russian], Nauka, Moscow (1964).
V. A. Tsyrlin and V. S. Gerasimenko, “The effect of pentobarbital and sodium hydroxybutyrate on the central mechanisms of regulation of vascular tone,” Byull. Éksperim. Biol. i Med., No. 12, 43 (1972).
T. Hayashi, “Historico do GABA e seus derivatos,” Hospital (Rio de Janeiro),75, 117 (1969).
M. Y. Purves, The Physiology of the Cerebral Circulation, Cambridge (1972).
A. Sato and R. F. Schmidt, “Somatosympathetic reflexes: Afferent fibers, central pathways, discharge characteristics,” Physiol. Rev.,53, 916 (1973).
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Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 80, No. 8, pp. 71–74, August, 1975.
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Bendikov, É.A., Gan'shina, T.S. Effect of sodium hydroxybutyrate on the regional circulation and nervous regulation of vascular tone. Bull Exp Biol Med 80, 937–940 (1975). https://doi.org/10.1007/BF00789275
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DOI: https://doi.org/10.1007/BF00789275