Skip to main content
SpringerLink
Log in

Systolic coronary flow reduction in the canine heart in situ: Effects of left ventricular pressure and elastance

  • Original Contribution
  • Published:
Basic Research in Cardiology Aims and scope Submit manuscript

Abstract

In the externally perfused coronary bed of the isolated heart, LV elastance (Elv) rather than LV pressure (Plv) appears to be the major factor responsible for systolic coronary flow reduction, although effects of both have been demonstrated. However, normal perfusion in the presence of intact autoregulation in the heart in situ may modify these effects. To investigate the systolic coronary flow (Qsyst) responses to changes in end-systolic Elv and in systolic Plv in the intact coronary bed, we studied 7 anesthetized dogs. Dogs were vagotomized, paced and instrumented with Doppler flow probes. Elv, obtained from micromanometer- and conductance-catheters, was changed by dobutamine infusion (10μg/kg/min) and characterized by its slope (Ees) and volume position at 15 kPa (V15). Plv was changed stepwise by volume loading. Correction for metabolism induced changes in Qmean was made. Thus, we found that dobutamine increased Ees by 44% (p<0.0001), decreased V15 by 43% (p<0.0001), and reduced corrected Qsyst significantly (p<0.001) from 22.8 to 13.8 ml/min, while Plv (9.5–19.5 kPa) did not affect corrected Qsyst (p>0.5). We conclude that systolic coronary flow reduction is related to both elastance parameters, Ees and V15, and not to Plv in the normally perfused canine heart in situ.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

ESPVR:

end-systolic pressure-volume relation

Ees :

end-systolic elastance (in kPa/ml)

V15 :

left ventricular volume at end-systolic pressure of 15 kPa (in ml)

LV:

left ventricular

LAD:

left anterior descending coronary artery

LCx:

left circumflex coronary artery

Qsyst :

systolic coronary blood flow

Qmean :

mean coronary blood flow

References

  1. Archie JP (1973) Determinants of regional intramyocardial pressure. J Surg Res 14: 338–346

    Google Scholar 

  2. Baan J, Van der Velde ET (1988) Sensitivity of left ventricular end-systolic pressure-volume relation to the type of loading intervention in dogs. Circ Res 62: 1247–1258

    Google Scholar 

  3. Baan J, Van der Velde ET, De Bruin HG et al. (1984) Continuous measurement of left ventricular volume in animals and humans by conductance catheter. Circulation 70: 812–823

    Google Scholar 

  4. Bouma P, Sipkema P, Westerhof N (1994) Vasomotor tone affects diastolic coronary flow and flow impediment by cardiac contraction similarly. Am J Physiol 266 (Heart Circ Physiol 35): H1944–1950

    Google Scholar 

  5. Doucette JW, Goto M, Flynn AE, Austin Jr RE, Husseini WK, Hoffman JIE (1993) Effects of cardiac contraction and cavity pressure on myocardial blood flow. Am J Physiol 265 (Heart Circ Physiol 34): H1342–1352

    Google Scholar 

  6. Downey JM, Kirk ES (1975) Inhibition of coronary blood flow by a vascular waterfall mechanism. Circ Res 36: 753–760

    Google Scholar 

  7. Elzinga G, Westerhof N (1973) Pressures and flow generated by the left ventricle against different impedances. Circ Res 32: 178–186

    Google Scholar 

  8. Glantz SA, Slinker BK (1990) Primer of applied regression and analysis of variance. McGraw-Hill, New York

    Google Scholar 

  9. Gregg DE, Green HD (1940) Registration and interpretation of normal phasic inflow into a left coronary artery by an improved differential manometric method. Am J Physiol 130: 114–125

    Google Scholar 

  10. Hoffman JIE, Spaan JAE (1990) Pressure-flow relations in coronary circulation. Physiol Rev 70 (2): 331–390

    Google Scholar 

  11. Iwanaga S, Ewing SG, Husseini WK, Hoffman JIE (1995) Changes in contractility and afterload have only slight effects on subendocardial systolic flow impediment. Am J Physiol 269 (Heart Circ Physiol 38): H1202–1212

    Google Scholar 

  12. Kouwenhoven E, Vergroesen I, Han Y, Spaan JAE (1992) Retrograde coronary flow is limited by time-varying elastance. Am J Physiol 263 (Heart Circ Physiol 32): H484–490

    Google Scholar 

  13. Krams R, Sipkema P, Westerhof N (1989) Contractility is the main determinant of coronary systolic flow impediment. Am J Physiol 257 (Heart Circ Physiol 26): H1936–1944

    Google Scholar 

  14. Krams, R, Sipkema P, Westerhof N (1989) Varying elastance concept may explain coronary systolic flow impediment. Am J Physiol 257 (Heart Circ Physiol 26): H1471–1479

    Google Scholar 

  15. Krams R, Van Haelst ACTA, Sipkema P, Westerhof N (1989) Can coronary systolic-diastolic flow differences be predicted by left ventricular pressure or time-varying intramyocardial elastance? Basic Res Cardiol 84: 149–159

    Google Scholar 

  16. Little WC, Cheng CP, Peterson T, Vinten Johanson J (1988) Response of the left ventricular end-systolic pressure-volume relation in conscious dogs to a wide range of contractile states. Circulation 78: 736–745

    Google Scholar 

  17. Nozawa T, Yasumura Y, Futaki S et al. (1987) Relation between oxygen consumption and pressure-volume area of the in-situ dog heart. Am J Physiol 253 (Heart Circ Physiol 22): H31–40

    Google Scholar 

  18. Olsson RA, Bugni WJ (1986) Coronary circulation. In: Fozzard et al. (ed). The Heart and Cardiovascular System. Raven Press, New York: 987–1037

    Google Scholar 

  19. Rabbany SY, Kresh JY, Noordergraaf A (1989) Intramyocardial pressure: interaction of myocardial fluid pressure and fiber stress. Am J Physiol 257 (Heart Circ Physiol 26): H357–364

    Google Scholar 

  20. Sarnoff SJ, Welch GH, Case RB, Stainsby WN, Macruz R, Braunwald E (1958) Hemodynamic determinants of oxygen consumption of the heart with special reference to the tension-time index. Am J Physiol 192: 148–156

    Google Scholar 

  21. Slinker BK, Glantz SA (1990) Missing data in a two-way analysis of variance. Am J Physiol 258 (Regul Integr Comp Physiol 27): R291–297

    Google Scholar 

  22. Spaan JAE (1985) Coronary diastolic pressure-flow relation and zero flow pressure explained on the basis of intramyocardial compliance. Circ Res 56: 293–309

    Google Scholar 

  23. Spaan JAE, Breuls NPW, Laird JD (1981) Diastolic-systolic coronary flow differences are caused by intramyocardial pump action in the anesthetized dog. Circ Res 49: 584–593

    Google Scholar 

  24. Suga H, Sagawa K, Shoukas AA (1973) Load independence of the instantaneous pressure-volume ratio of the left ventricle and effects of epinephrine and heart rate on the ratio. Circ Res 32: 314–322

    Google Scholar 

  25. Uhlig PN, Baer RW, Vlahakes GJ, Hanley FL, Messina LM, Hofman JIE (1984) Arterial and venous coronary pressure-flow relations in anesthetized dogs. Circ Res 55: 238–248

    Google Scholar 

  26. Van Bel F, Steendijk PS, Teitel DF, De Winter PJ, Van der Velde ET, Baan J (1992) Cerebral blood flow velocity the influence of myocardial contractinity on the velocity wave form of brain supplying arteries. Ultrasound Med Biol 18: 441–449

    Google Scholar 

  27. Van der Velde ET, Burkhoff D, Steendijk PS, Karsdon J, Sagawa K, Baan J (1991) Nonlinearity and load sensitivity of the end-systolic pressure-volume relation of the canine left ventricle in vivo. Circulation 83 (1): 315–327

    Google Scholar 

  28. Van Winkle DM, Swafford AN, Downey JM (1991) Subendocardial coronary compression in beating dog hearts is independent of pressure in the ventricular lumen. Am J Physiol 261 Heart Circ Physiol 30): H500–505

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cardiology, University Hospital of Leiden, Box 9600, 2300 RC, Leiden, The Netherlands

    J. Baan Jr., P. Steendijk & J. Baan

  2. Department of Internal Medicine, Hirosaki University Medical School, Hirosaki, Japan

    A. Mikuniya

Authors
  1. J. Baan Jr.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. Steendijk
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Mikuniya
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. Baan
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

A. Mikuniya was supported by the Royal Netherlands Academy of Arts and Sciences

Rights and permissions

Reprints and permissions

About this article

Cite this article

Baan, J., Steendijk, P., Mikuniya, A. et al. Systolic coronary flow reduction in the canine heart in situ: Effects of left ventricular pressure and elastance. Basic Res Cardiol 91, 468–478 (1996). https://doi.org/10.1007/BF00788728

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00788728

Key words

Search

Navigation