Summary
Investigations were conducted on rats with transplantation of sarcoma 45. These experiments in coordination with literature data, demonstrated that optical isomers of the antitumor preparation sarcolysin, i. e. DL-p-di-(2-chloroethyl) aminophenylalanine, although being similar by their toxic properties, were different in their biological activity. Considerable antitumor activity of L-form of sarcolysin, possessing a natural configuration of the molecule, in difference from an unnatural L-form confirms the belief that metabolite in the sarcolysin molecule plays a definite role in the mechanism of the antitumor effect of this preparation.
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Trusheikina, V.I. The antitumor activity of the optic isomers of sarcolysin. Bull Exp Biol Med 46, 1125–1128 (1958). https://doi.org/10.1007/BF00787949
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DOI: https://doi.org/10.1007/BF00787949