Abstract
The antitumor effect of a polymer of aspartic acid, polysuccinimide, against murine solid-tumor models, such as Lewis lung carcinoma, AKATOL adenocarcinoma, and Ca-755 adenocarcinoma was found. The tumor growth inhibition was 60–80% compared to the control. The antimetastatic activity of polysuccinimide was found; in the Lewis lung carcinoma model it manifests itself in inhibition of lung metastases by 60% compared to the control. It was shown that polysuccinimide does not shift the pH values of tumors (P-388 lympholytic leukemia, AKATOL adenocarcinoma) into the region of acidic values. The experimental study indicates the advisability of further profound preclinical trials of the antitumor properties and mechanism of action of polysuccinimide.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
D. B. Korman, Fundamentals of Antitumor Chemotherapy (Prakticheskaya Meditsina, Moscow, 2006) [in Russian].
D. B. Korman, Targets and Action Mechanisms of Antitumor Agents (Prakticheskaya Meditsina, Moscow, 2014) [in Russian].
V. M. Gol’dberg, S. M. Lomakin, A. V. Todinova, et al., Dokl. Ross. Akad. Nauk 423 (5), 423 (2008).
L. A. Ostrovskaya, S. D. Varfolomeev, M. G. Voronkov, et al., Izv. Ross. Akad. Nauk, Ser. Khim. 5, 1 (2014).
S. D. Varfolomeev, L. A. Ostrovskaya, D. B. Korman, et al., in MedChemRussia-2013: The First Russian Conference on Medical Chemistry with International Participation (Moscow, 2013), p. 293.
L. A. Ostrovskaya, S. D. Varfolomeev, D. B. Korman, et al., in Current Problems in Chemical Science and Pharmaceutics: Proc. All-Russia Conf. with International Participation (Pegas, Cheboksary, 2014), p. 188.
L. A. Ostrovskaya, S. D. Varfolomeev, D. B. Korman, et al., Ross. Bioterapevt. Zh. 3, 8 (2014).
E. M. Treshchalina, O. S. Zhukova, G. K. Gerasimova, et al., in Guidelines for Experimental (Preclinical) Studies on New Pharmacological Substances, 2nd ed., Ed. by R.U. Khabriev (Meditsina, Moscow, 2005), p. 637.
J. G. Mayo, Cancer Chemother. Repts. 3 (1), 325 (1972).
D. B. Korman, Vopr. Onkol. 60 (4), 449 (2014).
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © L.A. Ostrovskaya, D.B. Korman, S.D. Varfolomeev, V.A. Goldberg, M.M. Fomina, N.V. Bluhterova, V.A. Rikova, 2015, published in Biofizika, 2015, Vol. 60, No. 2, pp. 371–376.
Rights and permissions
About this article
Cite this article
Ostrovskaya, L.A., Korman, D.B., Varfolomeev, S.D. et al. Polysuccinimide: Experimental antitumor activity. BIOPHYSICS 60, 298–302 (2015). https://doi.org/10.1134/S000635091502013X
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S000635091502013X