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Calcium-activated K+ channels: Metabolic regulation

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Abstract

Calcium-activated potassium (KCa) channels are highly modulated by a large spectrum of metabolites. Neurotransmitters, hormones, lipids, and nucleotides are capable of activating and/or inhibiting KCa channels. Studies from the last few years have shown that metabolites modulate the activity of KCa channels via: (1) a change in the affinity of the channel for Ca2+ (K1/2 is modified), (2) a parallel shift in the voltage axis of the acitvation curves, or (3) a change in the slope (effective valence) of the voltage dependence curve. The shift of the voltage dependence curve can be a direct consequence of the change in the affinity for Ca2+. Recently, the mechanistic steps involved in the modulation of KCa channels are being uncovered. Some interactions may be direct on KCa channels and others may be mediated via G-proteins, second messengers, or phosphorylation. The information given in this review highlights the possibility that KCa channels can be activated or inhibited by metabolites without a change in the intracellular Ca2+ concentration.

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Authors and Affiliations

  1. Department of Molecular Physiology and Biophysics, Baylor College of Medicine, 77030, Houston, Texas

    L. Toro & E. Stefani

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  1. L. Toro
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  2. E. Stefani
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Toro, L., Stefani, E. Calcium-activated K+ channels: Metabolic regulation. J Bioenerg Biomembr 23, 561–576 (1991). https://doi.org/10.1007/BF00785811

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  • DOI: https://doi.org/10.1007/BF00785811

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