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Role of surface phenomena in the mechanism of action of antiarrhythmic drugs

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Surface activity of antiarrhythmic drugs and their effect on lipid-containing interphases were studied. Compound No. 7351 (diethylaminopropyl ester of diphenylisopropylacetic acid), Fubromegan, methyldiazine, propranolol, quinidine, novocainamide, xylocaine, and trimecaine were shown to be surface active. The curves of surface activity and, in particular, of interphase activity and those of antiarrhythmic action follow parallel courses. The most active antiarrhythmic compound (No. 7351) increased the electrical conductivity of a lecithin bilayer membrane much more strongly than novocainamide.

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Authors
  1. N. T. Pryanishnikova
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  2. V. M. Samvelyan
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  3. Zh. A. Dyadyura
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Pryanishnikova, N.T., Samvelyan, V.M. & Dyadyura, Z.A. Role of surface phenomena in the mechanism of action of antiarrhythmic drugs. Bull Exp Biol Med 82, 1811–1814 (1976). https://doi.org/10.1007/BF00785703

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  • DOI: https://doi.org/10.1007/BF00785703

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