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Effect of parathormone and thyrocalcitonin on Na,K-ATPase in cell membranes of rat brain and kidney

  • Biochemistry and Biophysics
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effect of parathormone (PH) and thyrocalcitonin (TCT) on ATPase enzyme systems of membrane preparations from the cerebral cortex and renal cortex of rabbits was studied in vitro and in vivo. Both in vitro and in vivo PH was found to increase the activity of transport Na,K-ATPase and Ca-activated ATPase in the cell membranes of the kidneys and brain. TCT produced similar, but much less marked changes in these ATPases only in experiments in vivo. Both hormones were virtually without effect on Mg-ATPase activity of the brain and kidney membranes. It is suggested that PH acts directly on membranous structures possessing Na,K-ATPase activity, whereas TCT acts indirectly on them.

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Authors
  1. V. V. Shkolovoi
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  2. R. N. Glebov
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Shkolovoi, V.V., Glebov, R.N. Effect of parathormone and thyrocalcitonin on Na,K-ATPase in cell membranes of rat brain and kidney. Bull Exp Biol Med 82, 1790–1792 (1976). https://doi.org/10.1007/BF00785696

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  • DOI: https://doi.org/10.1007/BF00785696

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