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The reflex effect of cardiovascular drugs arising from the venous receptors of the frog

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

The reflex effect on the heart and respiration of caffeine, strophantin, adrenalin and nitroglycerin was studied in conditions of perfusion of the humorally isolated femoral vein or of the whole frog's extremity. The impulse activity of the venous receptors was also registered.

These substances act on the receptors of the isolated parts of the vein and depress the respiration and cause motor reaction by reflex effect. However, they do not change the heart activity. Reflexes which come from receptors of the whole extremity stimulate respiration or cause motor reaction. The frequency of the afferent impulses from receptors of the femoral vein is increased by 5 to 10 times by the action of caffeine.

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Authors and Affiliations

  1. Department of Physiology of the Khabarovsk Medical Institute, Khabarovsk, USSR

    P. F. Konovalov

Authors
  1. P. F. Konovalov
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Submitted by Active Member of the AMN SSSR V. N. Chernigovskii

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Konovalov, P.F. The reflex effect of cardiovascular drugs arising from the venous receptors of the frog. Bull Exp Biol Med 45, 209–213 (1958). https://doi.org/10.1007/BF00784013

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  • DOI: https://doi.org/10.1007/BF00784013

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