Bulletin of Experimental Biology and Medicine

, Volume 59, Issue 1, pp 45–47 | Cite as

Effect of secretin on bile secretion under conditions of partial denervation of the liver

  • G. E. Saburov
Pathological Physiology and General Pathology


In experiments on dogs and cats at various periods after the supradiaphragmatic vagotomy, bilateral section of the greater splanchnic nerves or excision of spinal ganglia in the D5–D10 segments a study was made of bile secretion in response to the intravenous injection of purified secretin.

Disturbance of the parasympathetic innervation of the liver in dogs leads at difinite periods of time to a rise in the sensitivity of the hepatic secretory apparatus to secretin. In cats under similar conditions there is a drop of hepatic cell sensitivity to secretin. A rise of hepatic cell sensitivity to secretin was seen at definite periods after spinal deafferentation of the liver in dogs.

Partial loss of the sympathetic innervation by the liver, resulting from section of the greater splanchnic nerves, led to a marked reduction of the secretin sensitivity of hepatic secretory elements both in dogs and in cats.


Public Health Similar Condition Intravenous Injection Marked Reduction Hepatic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    V. S. Brangendler, Fiziol. zh. SSSR15, 1–2, p. 23 (1932).Google Scholar
  2. 2.
    E. I. Ginzburg, Method of Obtaining, Secretin [in Russian]. Diss. kand., Moscow (1947).Google Scholar
  3. 3.
    Z. V. Kobakhidze, Byull. éksper. biol. 6, 1 (1952).Google Scholar
  4. 4.
    E. S. London, The Physiology and Pathology of Digestion [in Russian], Pg. (1916).Google Scholar
  5. 5.
    O. G. Onisko, Byull. éksper. biol. 3. p. 7 (1958).Google Scholar
  6. 6.
    V. E. Robinson, Byull. éksper. biol., 2, p. 12 (1955).Google Scholar
  7. 7.
    Ts. V. Serbenyuk, Dokl. AN SSSR,75, 1, p. 145 (1960).Google Scholar
  8. 8.
    A. V. Solov'ev, Byull. éksper. biol.,28, 2, No. 2, p. 108 (1949).Google Scholar
  9. 9.
    G. V. Fol'bort, Russk. fiziol. zh.,1 1–2, p. 63 (1917).Google Scholar
  10. 10.
    G. V. Fol'bort and V. P. Adleberg, In the book: Collection Devoted to the 75th Anniversary of L. P. Pavlov [in Russian], Leningrad, p. 147 (1924).Google Scholar
  11. 11.
    G. Agren, J. Physiol., (London) (1939), Vol. 94, p. 553.Google Scholar
  12. 12.
    W. M. Bayliss and G. H. Starling (1902), vol. 28, p. 325.Google Scholar
  13. 13.
    M. H. F. Friedman and W. J. Snape, Fed. Proc. (1945), vol. 4, No. 1, p. 21.Google Scholar

Copyright information

© Consultants Bureau 1965

Authors and Affiliations

  • G. E. Saburov
    • 1
  1. 1.Department of Normal PhysiologyYaroslav Medical InstituteYaroslavUSSR

Personalised recommendations