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A study of the postvaccination immunity of guinea pigs repeatedly inoculated with a strain of brucella melitensis

Communication II

  • Microbiology and Immunity
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

The “break” of vaccinal immunity both in the steril and nonsterile phases led the authors to perform the following experiments: the vaccinal process was experimentally induced in guinea pigs by administration of the 19-BA, vaccine strain. The intensity of the sterile (postvaccinal) immunity was studied by repeated infection with a virulentBr. melitensis culture. It has been established that 17 1/2 months after immunization in 80% of cases the guinea pigs were still immune to a single infection withBr. melitensis. In reiterated infection with one month interval broken immunity was recorded in 70% of the cases, while a three-fold succession of infection with the same time interval—showed disrupted immunity in nearly 100% of the cases and a subsequent development of a generalized infection.

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Literature Cited

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Authors and Affiliations

  1. Brucellosis Division of the N. F. Gamaleya Institute of Epidemiology and Microbiology of the AMN SSSR, Moscow

    Sh. Khodzhaev

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  1. Sh. Khodzhaev
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Khodzhaev, S. A study of the postvaccination immunity of guinea pigs repeatedly inoculated with a strain of brucella melitensis. Bull Exp Biol Med 47, 486–490 (1959). https://doi.org/10.1007/BF00779632

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  • DOI: https://doi.org/10.1007/BF00779632

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